T wave alternans in an in vitro canine tissue model of Brugada syndrome

American Journal of Physiology. Heart and Circulatory Physiology
Hiroshi MoritaJiashin Wu

Abstract

Macroscopic T wave alternans (TWA) associated with increased occurrence of ventricular arrhythmias has been reported in patients with Brugada syndrome. However, the mechanisms in this syndrome are still unclear. We evaluated the hypothesis that TWA in Brugada syndrome was caused by the dynamic instability and heterogeneity of action potentials (APs) in the right ventricle. Using an optical mapping system, we mapped APs on the epicardium or transmural surfaces of 28 isolated and arterially perfused canine right ventricular preparations having drug-induced Brugada syndrome (in micromol/l: 2.5-15 pinacidil, 5.0 terfenadine, and 5.0-13 pilsicainide). Bradycardia at cycle length (CL) of 2,632 +/- 496 ms (n = 19) induced alternating deep and shallow T waves in the transmural electrocardiogram. Compared with the shallow T waves, deep T waves were associated with epicardial APs having longer durations and larger domes. Adjacent regions having APs with alternating domes, with constant domes, and without domes coexisted simultaneously in the epicardium and caused TWA. In contrast to the alternating epicardial APs, midmyocardial and endocardial APs did not change during TWA. Alternans could be terminated by rapid (CL: 529 +/- 168 ms, n = ...Continue Reading

References

Jun 1, 1994·Journal of the American College of Cardiology·W ZarebaW J Hall
Feb 1, 1993·Circulation·S C Krishnan, C Antzelevitch
Nov 1, 1995·Journal of Cardiovascular Pharmacology·Z Ming, C Nordin
Aug 1, 1996·The American Journal of Physiology·J M Di DiegoC Antzelevitch
Mar 23, 1999·Circulation·W Shimizu, C Antzelevitch
Apr 6, 2000·Pacing and Clinical Electrophysiology : PACE·H TadaK Taniguchi
May 18, 2001·American Journal of Physiology. Heart and Circulatory Physiology·J Wu, D P Zipes
Sep 6, 2002·Journal of Cardiovascular Electrophysiology·Masahiko TakagiJunichi Yoshikawa
Oct 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Jiashin Wu, Douglas P Zipes
Oct 22, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Jixin WangJoseph J Salata
Mar 6, 2003·Cardiovascular Research·Mariah L Walker, David S Rosenbaum
Mar 26, 2003·Cardiovascular Research·Hanno L TanArthur A M Wilde
Nov 11, 2003·Journal of the American College of Cardiology·Hiroshi MoritaTohru Ohe
Aug 28, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Norihiro UedaJiashin Wu
Apr 27, 2005·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Jeffrey M Fish, Charles Antzelevitch
Apr 27, 2005·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Norihiro UedaJiashin Wu

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Citations

Jun 26, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Charles Antzelevitch
Dec 17, 2008·Circulation Journal : Official Journal of the Japanese Circulation Society·Masayoshi KofuneAtsushi Hirayama
Mar 9, 2010·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Hiroshi MoritaJiashin Wu
Sep 1, 2009·Journal of Electrocardiology·Vladimir ShustermanBarry London
May 5, 2009·Journal of Theoretical Biology·Inma R CantalapiedraBlas Echebarria
Jun 30, 2007·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Charles Antzelevitch
Feb 6, 2007·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Hiroshi MoritaJiashin Wu
Nov 23, 2007·Journal of Cardiovascular Electrophysiology·Jeffrey M Fish, Charles Antzelevitch
Apr 26, 2014·Journal of Cardiovascular Electrophysiology·Yuko Uchimura-MakitaYasuki Kihara
Dec 18, 2013·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Adrian BaranchukPablo A Chiale
Mar 31, 2009·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Hiroshi MoritaJiashin Wu
Mar 29, 2016·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Natalia V Arteyeva, Jan E Azarov
Jan 3, 2007·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Hiroshi MoritaJiashin Wu
Apr 15, 2015·Journal of the Saudi Heart Association·Abdulrahman NaseefVelislav N Batchvarov
Nov 11, 2009·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Hiroshi MoritaJiashin Wu
Jun 30, 2001·Progress in Cardiovascular Diseases·T N James
Dec 15, 2015·Journal of the American Heart Association·Shuenn-Nan ChiuJiunn-Lee Lin
May 5, 2007·Current Opinion in Anaesthesiology·Luisa Santambrogio, Antonio Braschi
Apr 30, 2019·International Journal of Molecular Sciences·Franziska SendfeldRamon Brugada
Jun 24, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Beihua Zhong, Donna H Wang
Sep 19, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Stefania VecchiettiSilvio Cavalcanti

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