PMID: 11332561May 3, 2001Paper

T wave alternans threshold in normal children

Journal of Cardiovascular Electrophysiology
M M CheungJ L Wilkinson

Abstract

Sustained microvolt-level T wave alternans (TWA) during exercise is a predictor of ventricular arrhythmia propensity in adult populations. TWA occurs in normal adults, but it is rare at < 70% of predicted maximum heart rate. An onset heart rate < or = 110 is believed to be significant. The aim of this study was to examine the feasibility of performing the test in children and to determine the normal heart rate threshold for sustained TWA in children. Alternans was evaluated during bicycle exercise in 100 normal volunteers aged 8 to 17 years. Adequate resting data were obtained in 76 of 100 children and was negative in all. Exercise data from 16 of 100 was excluded due to excessive noise. Median maximum heart rate was 192 (range 140 to 214). Sustained alternans was absent in 75 (89%) of 84. In the nine children with sustained alternans, median onset heart rate was 138 (range 120 to 158), and 7 of 9 had an onset heart rate > or = 135. Median heart rate threshold as a percentage of predicted maximum heart rate (220 - age) was 67% (range 58% to 76%). Only 1 subject (1.2%) had an onset heart rate < 60% of predicted maximum. There was no significant difference between age, gender, endurance, maximum heart rate, QRS duration, QT inter...Continue Reading

Citations

Mar 23, 2011·International Journal of Cardiology·Shuenn-Nan ChiuMei-Hwan Wu
Jul 13, 2004·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Francesco FurlanelloRiccardo Cappato
Jul 16, 2009·Pacing and Clinical Electrophysiology : PACE·Robert M Hamilton, Eduardo R Azevedo
Aug 4, 2006·Pacing and Clinical Electrophysiology : PACE·Mark E AlexanderCharles I Berul
Nov 1, 2008·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Euler de Vilhena Garcia
Jun 5, 2010·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Leonid Makarov, Vera Komoliatova
Aug 9, 2006·The American Journal of Cardiology·Hui ZhaoRonald T Wakai
Feb 4, 2016·Circulation. Arrhythmia and Electrophysiology·Andrew M Davis
May 25, 2011·Circulation. Arrhythmia and Electrophysiology·Wouter Rudolph BergerAndrew Mark Davis
May 7, 2008·Critical Pathways in Cardiology·Ayman El-Menyar, Nidal Asaad

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