Cardiac "memory" refers to changes in T wave polarity induced by ventricular pacing that persist long after resumption of normal atrioventricular conduction. We studied the occurrence and mechanism of T wave changes in the open-chest anesthetized dog subjected to three discontinuous 20-minute periods of right ventricular pacing. ECG changes were recorded in the standard limb leads during normal conduction (prepacing) and three trains (T1, T2, and T3) of right ventricular pacing at a rate 50% higher than normal (pacing), each followed by a period of normal conduction (postpacing) lasting as long as necessary for T wave changes to return to control values. During each of these phases, heart rate, QRS, corrected QT (QTc) duration, and T wave amplitude were measured. In the first group (control), T wave inversions occurred during normal atrioventricular conduction after a period of right ventricular pacing. These T wave anomalies appeared in the absence of any change in heart rate, QRS, or QTc duration. The magnitude of the T wave amplitude change was significantly greater after each successive pacing period. Furthermore, the changes in T wave morphology persisted for a longer period after each successive pacing train. In a second ...Continue Reading
Effects of 4-aminopyridine on mechanical activity and noradrenaline release in the rat portal vein in vitro
Developmental sequelae of fixed-rate ventricular pacing in the immature canine heart: an electrophysiologic, hemodynamic, and histopathologic evaluation
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Cytostatic activity of pharmacological concentrations of indomethacin in cell cultures and inactivity of closely related compounds
Reversal of primary and pseudo-primary T wave abnormalities by ventricular pacing. A novel manifestation of cardiac memory
QRST time integral values in 12-lead electrocardiograms before and after radiofrequency catheter ablation in patients with Wolff-Parkinson-White syndrome
Body surface distribution of significant changes in QRST time-integral values after radiofrequency catheter ablation in patients with Wolff-Parkinson-White syndrome
Recovery of the right atrial effective refractory period after cardioversion of chronic atrial fibrillation
Electrophysiologic parameters and predisposing factors in the generation of drug-induced Torsade de Pointes arrhythmias
Functional, structural, and dynamic basis of electrical heterogeneity in healthy and diseased cardiac muscle: implications for arrhythmogenesis and anti-arrhythmic drug therapy
Specific alterations of endothelial signal transduction pathways of porcine epicardial coronary arteries in left ventricular hypertrophy
Novel method to assess cardiac electrophysiology in the rat: characterization of standard ion channel blockers
Key pathways associated with heart failure development revealed by gene networks correlated with cardiac remodeling
Modulation of the expression of long-term cardiac memory by short-term cardiac memory in patients with Wolff-Parkinson-White syndrome after catheter ablation
Activation-recovery intervals of 12-lead electrocardiograms before and after catheter ablation in patients with Wolff-Parkinson-White syndrome
Comparison of vectorcardiographic and 12-lead electrocardiographic detections of abnormalities in repolarization properties due to preexcitation in patients with Wolff-Parkinson-White syndrome: proposal of a novel concept of a "remodeling gradient"
Torsade de pointes secondary to d,l-sotalol after catheter ablation of incessant atrioventricular reentrant tachycardia--evidence for a significant contribution of the "cardiac memory"
Inhibition of HERG K+ current and prolongation of the guinea-pig ventricular action potential by 4-aminopyridine
Effect of short-term cardiac memory on ventricular electrical restitution and QT intervals in humans
Microtubules and angiotensin II receptors contribute to modulation of repolarization induced by ventricular pacing
Vectorcardiographic determinants of cardiac memory during normal ventricular activation and continuous ventricular pacing
Correlation of electrotonic monophasic action potential shortening with short-term memory in human atrium
Long-term changes in sequence of atrial activation and refractory periods: no evidence for "atrial memory"
Cardiac memory, a surface electrocardiographic clue in the differential diagnosis of ongoing narrow complex tachycardia
The zebrafish as a novel animal model to study the molecular mechanisms of mechano-electrical feedback in the heart
Body surface distribution of abnormally low QRST areas in patients with Wolff-Parkinson-White syndrome. Evidence for continuation of repolarization abnormalities before and after catheter ablation
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Cardiac Conduction System
The cardiac conduction system is a specialized tract of myocardial cells responsible for maintaining normal cardiac rhythm. Discover the latest research on the cardiac conduction system here.