T wave changes persisting after ventricular pacing in canine heart are altered by 4-aminopyridine but not by lidocaine. Implications with respect to phenomenon of cardiac 'memory'

Circulation
U del Balzo, Michael R Rosen

Abstract

Cardiac "memory" refers to changes in T wave polarity induced by ventricular pacing that persist long after resumption of normal atrioventricular conduction. We studied the occurrence and mechanism of T wave changes in the open-chest anesthetized dog subjected to three discontinuous 20-minute periods of right ventricular pacing. ECG changes were recorded in the standard limb leads during normal conduction (prepacing) and three trains (T1, T2, and T3) of right ventricular pacing at a rate 50% higher than normal (pacing), each followed by a period of normal conduction (postpacing) lasting as long as necessary for T wave changes to return to control values. During each of these phases, heart rate, QRS, corrected QT (QTc) duration, and T wave amplitude were measured. In the first group (control), T wave inversions occurred during normal atrioventricular conduction after a period of right ventricular pacing. These T wave anomalies appeared in the absence of any change in heart rate, QRS, or QTc duration. The magnitude of the T wave amplitude change was significantly greater after each successive pacing period. Furthermore, the changes in T wave morphology persisted for a longer period after each successive pacing train. In a second ...Continue Reading

References

Feb 1, 1979·The Journal of General Physiology·J L Kenyon, W R Gibbons
Jul 20, 1979·Naunyn-Schmiedeberg's Archives of Pharmacology·T Yanagisawa, N Taira
Aug 1, 1978·Annals of Internal Medicine·T R EngelR L Krause
Jan 1, 1977·Journal of Neural Transmission·E S ViziF F Foldes
Oct 1, 1987·Journal of Cardiovascular Pharmacology·Y MorikawaM R Rosen
Feb 1, 1989·Journal of Molecular and Cellular Cardiology·T NakayamaH A Fozzard
Apr 1, 1989·Circulation Research·G N Tseng, B F Hoffman
Nov 1, 1969·British Heart Journal·K ChatterjeeA Leatham
Nov 1, 1969·British Heart Journal·R J Kernohan
Feb 1, 1984·Circulation Research·I R JosephsonA M Brown
Feb 1, 1982·Pflügers Archiv : European journal of physiology·E Coraboeuf, E Carmeliet
May 1, 1982·Clinical Pharmacology and Therapeutics·D R UgesS Agoston
Aug 1, 1982·The American Journal of Cardiology·M B RosenbaumJ M Davidenko
Aug 1, 1982·The American Journal of Cardiology·B F Hoffman
Aug 1, 1982·The American Journal of Cardiology·B Surawicz
Sep 1, 1982·Pflügers Archiv : European journal of physiology·P P Van Bogaert, D J Snyders
Mar 1, 1981·Canadian Anaesthetists' Society Journal·E Martínez-AguirreH Velarde
Jul 1, 1981·Journal of Electrocardiology·P NicolaiA Pisapia
Oct 1, 1952·Circulation·H D LEVINER B STREEPER

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Citations

Dec 17, 2009·Biological cybernetics·Gairik SachdevaV S Chakravarthy
Mar 25, 2010·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Pablo A ChialeMarcelo V Elizari
Feb 12, 2004·Journal of Molecular and Cellular Cardiology·Kornelis W Patberg, Michael R Rosen
Jan 1, 1995·Journal of Electrocardiology·R Childers
Jan 1, 1995·Journal of Electrocardiology·M V Elizari, P A Chiale
Jan 1, 1997·Journal of Electrocardiology·H TachibanaH Tomoike
Mar 29, 2001·Lancet·M R Rosen
Aug 23, 2002·Pharmacology & Therapeutics·Michael Rosen, Alexei Plotnikov
Oct 3, 2002·The Journal of Emergency Medicine·James C Kolb
Jun 21, 2005·Journal of Cardiovascular Pharmacology·Christopher P ReganJoseph J Lynch
Aug 1, 1997·Pacing and Clinical Electrophysiology : PACE·A A Wilde, M W Veldkamp
Feb 27, 2007·Circulation Journal : Official Journal of the Japanese Circulation Society·Kun-Tai LeeWen-Ter Lai
Jun 4, 1999·Journal of Cardiovascular Electrophysiology·P RicardM R Rosen
Apr 29, 1998·Journal of Cardiovascular Electrophysiology·R GoyalF Morady
Oct 1, 1995·Journal of Cardiovascular Electrophysiology·M R Rosen
Jan 1, 1996·Journal of Cardiovascular Electrophysiology·B Surawicz
Nov 15, 2005·The Journal of Physiology·Michael R Rosen, Ira S Cohen
Mar 27, 2009·The Kaohsiung Journal of Medical Sciences·Kun-Tai LeeWen-Ter Lai
Jul 24, 2012·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Nazira ÖzgenMichael R Rosen
Apr 13, 2010·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Marti F A Bierhuizen, Marc A Vos
Jun 30, 2009·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Alexei ShvilkinMark E Josephson
Mar 28, 2009·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Nazira Ozgen, Michael R Rosen
Dec 7, 2007·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Eugene A SosunovMichael R Rosen
Mar 5, 2008·Mathematical Biosciences·J KrishnanS Radhakrishnan
Feb 27, 2007·International Journal of Cardiology·Kun-Tai LeeWen-Ter Lai
Dec 20, 2005·Pacing and Clinical Electrophysiology : PACE·Gi-Byoung NamJong-Min Lee
May 14, 2003·Journal of Cardiovascular Electrophysiology·Imad Libbus, David S Rosenbaum
May 10, 2007·Journal of Cardiovascular Electrophysiology·Dawood DarbarDan M Roden
Dec 13, 2005·Journal of Internal Medicine·M R Rosen, I S Cohen
Dec 23, 2009·Pacing and Clinical Electrophysiology : PACE·Darwin JeyarajDavid S Rosenbaum
Apr 27, 2005·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Dirk VollmannMaurits Allessie
Dec 3, 2005·International Journal of Cardiology·Maria Aunes-JanssonNils Edvardsson
Jul 28, 2012·Progress in Biophysics and Molecular Biology·Andreas A WerdichDavid S Rosenbaum
Nov 11, 2009·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Michael R Rosen
May 28, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Darwin JeyarajDavid S Rosenbaum

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