Abstract
This study aims to assess the capability of T-wave analysis to: 1) identify genotype-positive long QT syndrome (LQTS) patients; 2) identify LQTS patients with borderline or normal QTc interval (≤460 ms); and 3) classify LQTS subtype. LQTS often presents with a nondiagnostic electrocardiogram (ECG). T-wave abnormalities may be the only marker of this potentially lethal arrhythmia syndrome. ECGs taken at rest in 108 patients (43 with LQTS1, 20 with LQTS2, and 45 control subjects) were evaluated for T-wave flatness, asymmetry, and notching, which produces a morphology combination score (MCS) of the 3 features (MCS = 1.6 × flatness + asymmetry + notch) using QT Guard Plus Software (GE Healthcare, Milwaukee, Wisconsin). To assess for heterogeneity of repolarization, the principal component analysis ratio 2 (PCA-2) was calculated. Mean QTc intervals were 486 ± 50 ms (LQTS1), 479 ± 36 ms (LQTS2), and 418 ± 24 ms (control subjects) (p < 0.05). MCS and PCA-2 differed between LQTS patients and control subjects (MCS: 117.8 ± 57.4 vs. 71.9 ± 16.2; p < 0.001; PCA-2: 20.2 ± 10.4% vs. 14.6 ± 5.5%; p < 0.001), LQTS1 and LQTS2 patients (MCS: 96.3 ± 28.7 vs. 164 ± 75.2; p < 0.001; PCA-2: 17.8 ± 8.3% vs. 25 ± 12.6%; p < 0.001), and between LQTS p...Continue Reading
References
Aug 1, 1990·Circulation·J BenhorinL Cui
Nov 15, 1995·Circulation·A J MossM H Lehmann
Feb 1, 1994·Journal of the American College of Cardiology·G MalfattoP J Schwartz
Sep 1, 1994·Journal of the American College of Cardiology·M H LehmannR T Taggart
Dec 31, 1997·Circulation·S G PrioriP J Schwartz
Jan 11, 2000·Circulation·L ZhangA Medina
Dec 4, 2003·Journal of the American College of Cardiology·Susan P EtheridgeJay W Mason
Apr 21, 2005·Heart Rhythm : the Official Journal of the Heart Rhythm Society·David J TesterMichael J Ackerman
Apr 27, 2005·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Jørgen K KantersMichael Christiansen
Nov 30, 2005·British Journal of Pharmacology·Kazunobu KawakamiYasuhide Nakashima
Mar 15, 2006·Circulation·Himeshkumar VyasMichael J Ackerman
Aug 29, 2006·Medical & Biological Engineering & Computing·J J StruijkE Toft
Jan 24, 2007·Journal of the American College of Cardiology·Ian TopilskiSami Viskin
May 16, 2007·Circulation·Nathaniel W TaggartMichael J Ackerman
Jul 30, 2008·Journal of Cardiovascular Electrophysiology·Arthur J MossJennifer L Robinson
Sep 23, 2008·Journal of Electrocardiology·Mads P AndersenJohannes J Struijk
Jan 30, 2009·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Joel Q Xue
Jun 18, 2009·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Claus GraffJohannes J Struijk
Feb 27, 2010·Journal of the American College of Cardiology·Barbara J DrewUNKNOWN American College of Cardiology Foundation
Oct 19, 2013·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Laura CalvilloPeter J Schwartz
Sep 27, 2014·Journal of the American College of Cardiology·Abeer Abu-ZeitoneArthur J Moss
Citations
Jun 17, 2020·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Jens Cosedis NielsenChristophe Leclercq
Aug 13, 2020·Journal of Arrhythmia·Jens Cosedis NielsenChristophe Leclercq
Mar 3, 2019·Herzschrittmachertherapie & Elektrophysiologie·B BrüggemannC Zormpas
Jan 27, 2021·Journal of Cardiothoracic and Vascular Anesthesia·Naoko NiimiKatherine Zaleski
Dec 16, 2020·International Journal of Cardiology·Jonas L IsaksenJørgen K Kanters
Feb 23, 2021·Frontiers in Cardiovascular Medicine·Gary TseWing Tak Wong
Aug 31, 2021·Biochemical Pharmacology·Michelle Vanessa Kapchoup KamgaFilomain Nguemo
Sep 2, 2021·European Heart Journal·Edi PriftiJoe-Elie Salem