T1ρ MRI of healthy and fibrotic human livers at 1.5 T

Journal of Translational Medicine
Anup SinghRavinder Reddy

Abstract

Liver fibrosis is a public health problem worldwide. There is a need of noninvasive imaging based methods for better diagnosis of this disease. In the current study, we aim to evaluate the potential of T1ρ MRI technique in detecting and characterizing different grades of liver fibrosis in vivo in humans. Healthy subjects and patients with liver fibrosis were prospectively recruited for T1ρ MRI of liver on a 1.5 T MR scanner. Single slice T1ρ weighted images were acquired at different spin lock duration (0, 10, 20 and 30 ms) with spin lock amplitude of 500 Hz in a single breath-hold. Additionally, liver's T1ρ images were acquired from five healthy subjects on the same day (n = 2) and different day (n = 2) sessions for test-retest study. Liver biopsy samples from patients were obtained and used to calculate the METAVIR score to define the stage of fibrosis and inflammation grade. T1ρ maps were generated followed by computation of mean and standard deviation (SD) values. Coefficient of variation (COV) of T1ρ values between two MRI scans was computed to determine reproducibility in liver. T test was used to compare T1ρ values between healthy and fibrotic liver. Pearson correlation was performed between stages of liver fibrosis and ...Continue Reading

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Citations

Dec 13, 2016·Expert Review of Gastroenterology & Hepatology·Emre UnalMuşturay Karçaaltıncaba
Sep 1, 2017·Topics in Magnetic Resonance Imaging : TMRI·Léonie PetitclercAn Tang
Jan 23, 2019·Journal of Magnetic Resonance Imaging : JMRI·Stefanie J HectorsBachir Taouli
Nov 2, 2017·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Shuangshuang XieWen Shen
Feb 20, 2020·Journal of Magnetic Resonance Imaging : JMRI·Stefanie J HectorsBachir Taouli
Sep 15, 2020·Abdominal Radiology·Paul KennedyBachir Taouli
Dec 17, 2016·Journal of Magnetic Resonance Imaging : JMRI·Léonie PetitclercAn Tang
Aug 31, 2018·Current Gastroenterology Reports·Rishi Philip Mathew, Sudhakar Kundapur Venkatesh
Nov 8, 2017·Magnetic Resonance Imaging·Weibo ChenDongrong Xu
Nov 19, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Carlos VelascoClaudia Prieto
Nov 21, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Carlos VelascoClaudia Prieto

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Methods Mentioned

BETA
biopsy
biopsies

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