t10,c12 Conjugated linoleic acid induces compensatory growth after immune challenge

The Journal of Nutritional Biochemistry
Daniel ButzMark E Cook

Abstract

Previous work demonstrated that feeding commercial preparations of conjugated linoleic acid (CLA) [a 50:50 mixture of c9,t11 and t10,c12 CLA (cCLA)] partially overcame lipopolysaccharide (LPS)-induced growth depression. The objective of this study was to determine which CLA isomer was responsible for the reduction of LPS-induced growth depression. Dietary cCLA supplementation for 3 weeks protected mice from LPS-induced weight loss 24 h after injection compared to mice fed isocaloric and isonitrogenous control diets supplemented with either corn oil (CO) or a mixture of CO and olive oil. Dietary c9,t11 or t10,c12 CLA led to body weight loss intermediate to controls and cCLA. After LPS-induced weight loss, the t10,c12 CLA fed mice regained weight faster than the control or c9,t11 CLA fed mice. Dietary t10,c12 CLA and cCLA reduced plasma tumor necrosis factor 2 h after LPS stimulation. While neither c9,t11 nor t10,c12 CLA isomers alone protected from immune-induced weight loss, the t10,c12 CLA isomer induced compensatory gain.

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Citations

Jun 19, 2007·European Journal of Pharmacology·Sun Jin Hur, Yeonhwa Park
Aug 8, 2006·European Journal of Pharmacology·Guangming LiMark E Cook
Nov 11, 2009·Rapid Communications in Mass Spectrometry : RCM·Daniel E ButzWarren P Porter
Jun 8, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Daniel E ButzMark E Cook
Nov 29, 2013·The Journal of Nutrition·Shane M HuebnerMark E Cook
Nov 12, 2020·Journal of Agricultural and Food Chemistry·Jiankang WangFereidoon Shahidi

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