PMID: 7522039Jul 1, 1994Paper

t(1;19) without detectable E2A rearrangements in two t(14;18)-positive lymphoma/leukemia cases

Genes, Chromosomes & Cancer
I WlodarskaH Van den Berghe

Abstract

Translocation t(1;19)(q23;p13) plays a crucial role in the pathogenesis of childhood pre-B cell leukemia and results in the formation of a fusion gene E2A-PBX1 that encodes a hybrid transcription factor with oncogenic potential. Here we describe two cases, one follicular lymphoma and one acute lymphoblastic leukemia/lymphoma, characterized by a complex karyotype including t(14;18), t(8;14), as well as t(1;19). Molecular studies in both cases failed to show rearrangements of the E2A gene. These results suggest that the t(1;19) found as a secondary chromosome change in t(14;18)-positive lymphoma/leukemia might be a molecular variant of the t(1;19) that is typical of childhood pre-B cell leukemia.

References

Nov 22, 1984·The New England Journal of Medicine·S Murphy, E S Jaffe
Dec 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·R Dalla-FaveraC M Croce

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