T11TS inhibits Angiopoietin-1/Tie-2 signaling, EGFR activation and Raf/MEK/ERK pathway in brain endothelial cells restraining angiogenesis in glioma model

Experimental and Molecular Pathology
Debanjan BhattacharyaSwapna Chaudhuri

Abstract

Malignant gliomas represent one of the most aggressive and hypervascular primary brain tumors. Angiopoietin-1, the peptide growth factor activates endothelial Tie-2 receptor promoting vessel maturation and vascular stabilization steps of angiogenesis in glioma. Epidermal growth factor receptor (EGFR) and Tie-2 receptor on endothelial cells once activated transmits signals through downstream Raf/MEK/ERK pathway promoting endothelial cell proliferation and migration which are essential for angiogenesis induction. The in vivo effect of sheep erythrocyte membrane glycopeptide T11-target structure (T11TS) on angiopoietin-1/Tie-2 axis, EGFR signaling and Raf/MEK/ERK pathway in glioma associated endothelial cells has not been investigated previously. The present study performed with rodent glioma model aims to investigate the effect of T11TS treatment on angiopoietin-1/Tie-2 signaling, EGFR activity and Raf/MEK/ERK pathway in glioma associated endothelial cells within glioma milieu. T11TS administration in rodent glioma model inhibited angiopoietin-1 expression and attenuated Tie-2 expression and activation in glioma associated brain endothelial cells. T11TS treatment also downregulated total and phosphorylated EGFR expression in glio...Continue Reading

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Citations

Feb 25, 2017·Journal of Cellular Physiology·Somnath MondalSwapna Chaudhuri
Apr 25, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Simon S LavoieMartin G Sirois
May 14, 2019·The FEBS Journal·Mathias Declercq, Lucas Treps
Jul 13, 2019·Expert Opinion on Pharmacotherapy·Hasenin Al-KhersanPravin U Dugel
Dec 26, 2015·Marine Drugs·Javier A García-VilasMiguel Ángel Medina
Feb 8, 2020·Clinical and Experimental Pharmacology & Physiology·Meixiong Cheng, Ling Liu
Feb 13, 2020·Current Pharmaceutical Design·Andrea E TothMorten S Nielsen

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