PMID: 7515661Mar 1, 1994Paper

t(12;21): a new recurrent translocation in acute lymphoblastic leukemia

Genes, Chromosomes & Cancer
S P RomanaR Berger

Abstract

A t(12;21)(p11-p12;q22) was detected by chromosome painting in three patients with acute lymphoblastic leukemia (ALL) among eight ALL cases with 12p- abnormalities. The three leukemias had similar immunophenotypes (DR+, CD10+, CD19+). Fluorescence in situ hybridization (FISH) experiments using YAC clones from 21q21-q22 were performed to better localize the breakpoint on chromosome 21. This breakpoint was localized to 21q22.2 in one patient. Although only one case of ALL with t(12;21) has been reported previously, the present results suggest that t(12;21) is a recurrent translocation in ALL.

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Citations

Mar 10, 2001·Genes, Chromosomes & Cancer·H ElghezalS P Romana
Oct 2, 2001·Genes, Chromosomes & Cancer·M Busson-Le ConiatR Berger
May 1, 1995·Genes, Chromosomes & Cancer·H RiederC Fonatsch
Nov 1, 1995·Genes, Chromosomes & Cancer·M Le ConiatR Berger
Dec 26, 2008·International Journal of Hematology·Young Joo KwonHack Ki Kim
Apr 28, 2004·Leukemia Research·Françoise BrizardAndré Brizard
Jul 10, 2003·Gastroenterology·Virginie VerkarreIsabelle Radford-Weiss
Apr 18, 2003·Cancer Genetics and Cytogenetics·Roland Berger, Maryvonne Busson-Le Coniat
Jul 10, 2003·Cancer Genetics and Cytogenetics·Nathalie Douet-GuilbertMarc De Braekeleer
Jan 22, 2004·Cancer Genetics and Cytogenetics·Jeanna WelbornPaula Walling
Mar 1, 1997·Cancer Genetics and Cytogenetics·R Berger
Oct 23, 1997·Cancer Genetics and Cytogenetics·Y L Kwong, K F Wong
Apr 13, 1999·Cancer Genetics and Cytogenetics·D H SpathasJ M Connor
Oct 14, 1998·Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie·F Salomon-NguyenR Berger
Jul 27, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M R Teixeira
Feb 10, 2006·Leukemia·S P RomanaUNKNOWN Groupe Francophone de Cytogénétique Hématologique
May 23, 1995·Proceedings of the National Academy of Sciences of the United States of America·T R GolubD G Gilliland
Oct 31, 2009·Journal of Pediatric Hematology/oncology·Louise Olde NordkampHenk van den Berg
Feb 3, 1999·Annual Review of Genetics·J D Rowley
Jan 6, 2010·Advances in Hematology·Abir GmidèneAli Saad
Dec 25, 2010·The Journal of Clinical Investigation·Aude Magerus-ChatinetFrédéric Rieux-Laucat
Jul 31, 2013·Epigenomics·Melanie R HasslerGerda Egger
Mar 20, 1999·Current Opinion in Pediatrics·A BorkhardtF Lampert
Apr 10, 2002·Clinical Genetics·D SanlavilleM Vekemans
Oct 11, 2008·Magyar onkologia·Irén HaltrichGyörgy Fekete

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