t(14;18)(q32;q21) involving IGH and MALT1 is uncommon in cutaneous MALT lymphomas and primary cutaneous diffuse large B-cell lymphomas

Journal of Cutaneous Pathology
Nicholas T WongchaowartJames R Cook

Abstract

t(14;18)(q32;q21) involving IGH and MALT1 has been demonstrated in cutaneous MALT lymphomas and in one case of primary cutaneous diffuse large B-cell lymphoma (DLBCL). However, the incidence of IGH/MALT1 translocations in these forms of cutaneous lymphoma remains unclear. We performed paraffin section interphase fluorescence in situ hybridization (FISH) analysis using MALT1 and IGH break-apart probes on 16 cutaneous MALT lymphomas and 16 primary cutaneous DLBCL in order to assess the frequency of IGH/MALT1 translocations and to screen for other potential translocations involving the IGH or MALT1 loci. Translocations involving MALT1 were not detected in any of 16 cutaneous MALT lymphomas or 16 primary cutaneous DLBCL. Of the 12 MALT lymphomas that could be analyzed for an IGH translocation, all were negative. In contrast, four of the 13 cases (31%) of primary cutaneous DLBCL that could be analyzed for translocations involving IGH were positive. Subsequent FISH analysis demonstrated one of these to be an IGH/BCL2 translocation and one to be a CMYC/IGH translocation, while the translocation partners in the remaining two cases are currently unidentified. This study demonstrates that translocations involving MALT1, including IGH/MAL...Continue Reading

References

May 8, 2000·Hematological Oncology·J DierlammD K Hossfeld
Sep 15, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·N S AguileraS L Abbondanzo
Feb 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·I MirzaE D Hsi
Mar 21, 2002·The Lancet Oncology·Ming-Qing Du, Peter G Isaccson
Feb 1, 2003·Blood·Dolors Sanchez-IzquierdoJose Angel Martinez-Climent
Jul 29, 2003·The American Journal of Surgical Pathology·Chunmei LiTadaaki Eimoto
Nov 14, 2003·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Sang Geol KimAsif Rashid
Feb 5, 2005·Blood·Rein WillemzeChris J L M Meijer
Apr 16, 2005·The American Journal of Surgical Pathology·Thomas WiesnerLorenzo Cerroni

❮ Previous
Next ❯

Citations

Sep 30, 2008·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Hisashi TakinoHiroshi Inagaki
May 23, 2013·The American Journal of Dermatopathology·Angel Fernandez-Flores
Feb 4, 2012·The American Journal of Surgical Pathology·Shannon BieliauskasJames R Cook
Dec 6, 2012·Pathology Research International·Philipp W Raess, Adam Bagg
Apr 1, 2014·Journal of the American Academy of Dermatology·Alya Abdul-WahabSean Whittaker
Apr 17, 2009·American Journal of Clinical Pathology·Matthew T HowardJames R Cook
Jan 26, 2010·Actas dermo-sifiliográficas·L Cerroni, T Wiesner
Mar 4, 2008·Virchows Archiv : an International Journal of Pathology·Marc-Antoine Belaud-RotureauJean-Philippe Merlio

❮ Previous
Next ❯

Related Concepts

Related Feeds

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.