T2 and T2* mapping in patients after matrix-associated autologous chondrocyte transplantation: initial results on clinical use with 3.0-Tesla MRI.

European Radiology
G H WelschT C Mamisch

Abstract

To use T2 and T2* mapping in patients after matrix-associated autologous chondrocyte transplantation (MACT) of the knee, and to compare and correlate both methodologies. 3.0-Tesla MRI was performed on 30 patients (34.6 +/- 9.9 years) with a follow-up period of 28.1 +/- 18.8 months after MACT. Multi-echo, spin-echo-based T2 mapping using six echoes and gradient-echo-based T2* mapping using six echoes were prepared. T2 and T2* maps were obtained using a pixel-wise, mono-exponential, non-negative least-squares fit analysis. Region-of-interest analysis was performed for mean (full-thickness) as well as deep and superficial aspects of the cartilage repair tissue and control cartilage sites. Mean T2 values (ms) were comparable for the control cartilage (53.4 +/- 11.7) and the repair tissue (55.5 +/- 11.6) (p > 0.05). Mean T2* values (ms) for control cartilage (30.9 +/- 6.6) were significantly higher than those of the repair tissue (24.5 +/- 8.1) (p < 0.001). Zonal stratification was more pronounced for T2* than for T2. The correlation between T2 and T2* was highly significant (p < 0.001), with a Pearson coefficient between 0.276 and 0.433. T2 and T2* relaxation time measurements in the evaluation of cartilage repair tissue and its zo...Continue Reading

References

Oct 1, 1980·Annals of the Rheumatic Diseases·A MaroudasM F Venn
Feb 5, 2000·AJR. American Journal of Roentgenology·D W GoodwinJ F Dunn
Oct 21, 2000·Investigative Radiology·D BursteinM L Gray
Jan 9, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·D BursteinM L Gray
Jul 4, 2001·Journal of Magnetic Resonance Imaging : JMRI·H E SmithM B Smith
Oct 18, 2001·Clinical Orthopaedics and Related Research·A R PooleS Laverty
Dec 5, 2002·Osteoarthritis and Cartilage·C LiessC-C Glüer
May 2, 2003·The Journal of Bone and Joint Surgery. American Volume·Mats Brittberg, Carl S Winalski
Aug 20, 2003·The Journal of Bone and Joint Surgery. American Volume·Mats BrittbergAnders Lindahl
Feb 3, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Karla L MillerJohn M Pauly
Mar 3, 2004·Journal of Magnetic Resonance Imaging : JMRI·Timothy J MosherMichael B Smith
Oct 1, 2004·Arthritis and Rheumatism·Timothy J MosherMichael B Smith
Jan 12, 2005·Seminars in Musculoskeletal Radiology·Timothy J Mosher, Bernard J Dardzinski
May 17, 2005·Radiologic Clinics of North America·Christian Glaser
Jun 28, 2006·European Radiology·S TrattnigS Marlovits
Aug 12, 2006·Osteoarthritis and Cartilage·D Burstein, M L Gray
Oct 3, 2007·The Journal of Bone and Joint Surgery. American Volume·Gunnar KnutsenOddmund Johansen
Feb 13, 2008·Proceedings of the National Academy of Sciences of the United States of America·Wen LingAlexej Jerschow
Jul 19, 2008·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Yun Sun ChoiTong Jin Chun
Sep 26, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Tallal Charles MamischYoung-Jo Kim
Sep 30, 2008·Journal of Magnetic Resonance Imaging : JMRI·Goetz H WelschTallal C Mamisch
Oct 14, 2008·Seminars in Musculoskeletal Radiology·Goetz H WelschSiegfried Trattnig

❮ Previous
Next ❯

Citations

Oct 31, 2013·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Rachel K SurowiecCharles P Ho
Dec 3, 2014·Magnetic Resonance Imaging Clinics of North America·Richard Kijowski, Rajeev Chaudhary
Mar 26, 2013·Clinical Imaging·Maija RossiPrasun Dastidar
Jun 15, 2011·Magnetic Resonance Imaging Clinics of North America·Jung-Ah Choi, Garry E Gold
Mar 18, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Julio Carballido-GamioSharmila Majumdar
Nov 21, 2012·Journal of Magnetic Resonance Imaging : JMRI·Miika T NieminenIlkka Kiviranta
May 3, 2014·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Arin M EllingsonDavid J Nuckley
Oct 20, 2015·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Ans Van Ginckel, Erik E Witvrouw
Feb 27, 2016·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Ans Van GinckelErik E Witvrouw
Apr 30, 2021·Journal of Experimental Orthopaedics·Hasan BanitalebiPer-Henrik Randsborg
Sep 23, 2021·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Abbas ShokriLobat Tayebi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.