T2 mapping in dermatomyositis/polymyositis and correlation with clinical parameters

Clinical Radiology
J RanX Li

Abstract

To explore the T2-mapping signal characteristics of the thigh muscles in patients with dermatomyositis/polymyositis (DM/PM) and to investigate the correlation between thigh muscle T2 values, clinical parameters, and serum creatinine kinase (CK). Forty-two patients with DM/PM proven by diagnostic criteria were enrolled in the study along with 13 healthy control subjects. Both T2-mapping and conventional magnetic resonance imaging (MRI) images were obtained in the thigh musculature of all subjects. The T2 values of thigh muscles were compared between the DM/PM patients and control groups. Thirty-one DM/PM patients were evaluated with manual muscle testing (MMT) and serum CK levels. A Spearman correlation coefficient model was used to correlate the mean T2 values and clinical assessments. The Kruskal-Wallis test and receiver operating characteristic (ROC) curves were also utilised. p-Values <0.05 reflected statistical significance. The T2 value of all oedematous muscles was greater on average than that of the unaffected muscles of the DM/PM patients (p<0.05) and the muscles of healthy volunteers (p<0.05). The T2 value of unaffected muscles in DM/PM patients was also greater than that of the normal muscles in healthy volunteers (p<...Continue Reading

Citations

May 22, 2020·Acta Neurologica Scandinavica·Hans-Jonas MeyerAlexey Surov
Jul 8, 2019·Journal of the American Academy of Dermatology·Reid WaldmanJun Lu
Oct 13, 2020·Medicine and Science in Sports and Exercise·Hoai-Thu NguyenMagalie Viallon
Jun 2, 2021·The Medical Clinics of North America·Kylee J B KusRuth Ann Vleugels
Aug 24, 2021·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Junqin ZhangShudong Hu

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