T2 mapping MRI technique quantifies carotid plaque lipid, and its depletion after statin initiation, following acute myocardial infarction

Atherosclerosis
Mohammad AlkhalilRobin P Choudhury

Abstract

A recently-validated, highly-sensitive T2 mapping magnetic resonance (MRI) technique accurately quantifies carotid plaque lipid. The aims of this study were to determine: (i) the extent of carotid plaque lipid in patients with acute coronary syndromes (ACS); (ii) the effects of initiation of high-intensity statin on plaque lipid content and (iii) whether plaque lipid content is related to standard or 'functional' blood lipid measurements. Statin naïve subjects presenting with ACS underwent carotid artery MRI at 3 T scanner to quantify plaque lipid. Patients were subsequently commenced on high dose statin as part of clinical care and underwent a second MRI after three months. Plaque composition was measured using objective semi-automated techniques. 23 out of 24 patients had measurable lipid. Three months after statin initiation there was a significant reduction in carotid lipid percentage [from 10.3% (7.2-14.2) to 7.4% (5.4-10.0), p = 0.002] and a significant increase in fibrous percentage [from 83.3% ± 6.6-85.5% ± 4.8, p = 0.039]. None of the studied functional blood biomarkers were related to either baseline carotid plaque lipid content or its propensity to change with statin treatment. T2-mapping demonstrated depleted caroti...Continue Reading

Citations

Mar 29, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·Rob C I WüstGustav J Strijkers
Nov 8, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Robert FrostPeter Jezzard
Jun 17, 2019·JACC. Cardiovascular Imaging·Mohammad Alkhalil, Robin P Choudhury
Jul 10, 2019·Current Problems in Cardiology·Mohammad Alkhalil
Feb 16, 2021·Journal of the American Heart Association·Mohammad AlkhalilVladimír Džavík
Mar 7, 2021·Biomedicines·Kristina AndelovicAlma Zernecke

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