T280M variation of the CX3C receptor gene is associated with increased risk for severe respiratory syncytial virus bronchiolitis

The Pediatric Infectious Disease Journal
Virginia AmanatidouDemetrios A Spandidos

Abstract

Recent data suggest that immunologic response during respiratory syncytial virus (RSV) infection is partially modified through interaction of viral G glycoprotein with the host's chemokine receptor, CX3CR1. We hypothesized that two nonsynonymous, single-nucleotide polymorphisms of the CX3CR1 gene (CX3CR1-V249I and CX3CR1-T280M) that disrupt the affinity of CX3CR1 for its natural ligand (fractalkine) could also affect the G glycoprotein-CX3CR1 pathway. To test the hypothesis, DNA samples were obtained from 82 children hospitalized for RSV bronchiolitis in a 1-year period. One hundred twenty sex-matched healthy adults, without a history of severe lower respiratory tract infections, formed the control group. Epidemiologic data showed an increase in the RSV infection rate during the late winter season, with a peak rate in early spring. Genotyping revealed predominance of the 280M-containing genotypes (M/M or T/M) in cases compared with controls (37.8% versus 20.8%, respectively; odds ratio, 2.03; 95% confidence interval, 1.1-3.9; P = 0.025), demonstrating an association between the common CX3CR1-T280M variations and increased risk of severe RSV bronchiolitis. Our findings support the hypothesis of the pivotal role of the G glycopro...Continue Reading

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Citations

Dec 29, 2007·The Pediatric Infectious Disease Journal·Virginia AmanatidouDemetrios A Spandidos
Dec 25, 2008·The Pediatric Infectious Disease Journal·Virginia AmanatidouDemetrios A Spandidos
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