T3 subclassification using the EMD/mesorectum ratio predicts neoadjuvant chemoradiation outcome in T3 rectal cancer patients

The British Journal of Radiology
Lijun ShenZhen Zhang

Abstract

To evaluate the feasibility of the EMD (extramural depth)/mesorectum ratio as a marker for T3 rectal cancer and its ability to predict tumour response to neoadjuvant chemoradiation and survival. From 2010 to 2016, 284 T3 rectal cancer patients who underwent high resolution MRI before neoadjuvant chemoradiation were enrolled. The EMD was defined as the distance from the outer edge of the muscularis propria to the outermost edge of the tumour. The measurement of the tumour EMD and mesorectum was in the same layer and their ratio was calculated. Receiver operating characteristic analysis and relative area under the curve statistics were used to choose the cut-off value. The association of the EMD/mesorectum ratio and other MRI or clinical factors with the tumour regression grade (TRG) was analysed. Cox regression analysis was used to estimate independent risk factors for disease-free survival (DFS) and overall survival (OS). The mean EMD/mesorectum ratio was 0.47 ± 0.3. We chose an EMD/mesorectum ratio of 0.5 in further analyses after receiver operating characteristic analysis. Of 284 patients, 177 (62.3%) had an EMD/mesorectum ratio ≤ 0.5. Patients with an EMD/mesorectum ratio ≤ 0.5 had a higher TRG 0-1 rate than patients with a ...Continue Reading

References

Sep 8, 2001·The New England Journal of Medicine·E KapiteijnUNKNOWN Dutch Colorectal Cancer Group
Nov 1, 2001·International Journal of Colorectal Disease·S MerkelP Hermanek
Oct 22, 2004·The New England Journal of Medicine·Rolf SauerUNKNOWN German Rectal Cancer Study Group
Sep 15, 2006·The New England Journal of Medicine·Jean-François BossetUNKNOWN EORTC Radiotherapy Group Trial 22921
Feb 25, 2010·Annals of Surgical Oncology·Stephen B Edge, Carolyn C Compton
Nov 9, 2012·Diseases of the Colon and Rectum·Rumi ShinJae-Gahb Park
Oct 23, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·B GlimeliusUNKNOWN ESMO Guidelines Working Group
Nov 26, 2013·Surgical Oncology Clinics of North America·Martin R WeiserGerard Beets
May 23, 2014·AJR. American Journal of Roentgenology·Seung Hyun ChoUNKNOWN Society of North America (RSNA)
Aug 12, 2014·Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progrès Dans Les Recherches Sur Le Cancer·Rob Glynne-Jones
Dec 3, 2014·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Aldo SainatoLuca Cionini
Mar 5, 2016·AJR. American Journal of Roentgenology·Kartik S JhaveriRichard Kirsch
Nov 25, 2016·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·R ZinicolaR J Nicholls

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Citations

Aug 16, 2019·Der Radiologe·I Iesalnieks, A Agha

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