t(3;14)(p14.1;q32)/FOXP1-IGH translocation in thyroid extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma)

Leukemia Research
Yosuke SasakiToshiko Yamochi-Onizuka

Abstract

MALT lymphoma occurs in various organs and has several characteristic genetic aberrations. Thyroid MALT lymphoma has been reported to include t(3;14)(p14.1;q32)/FOXP1-IGH as a specific genetic aberration, but the number of studies is limited. We examined 86 thyroid lymphoma cases using fluorescence in situ hybridization (FISH) for the detection of t(3;14)/FOXP1-IGH in formalin fixed paraffin-embedded tissue (FFPE). Histopathological diagnoses of the analyzed specimen were as follows: thyroid MALT lymphoma (n = 59), DLBCL (n = 23), follicular lymphoma (n = 4), and benign lesions (n = 14) included Hashimoto's thyroiditis (n = 13) and other (n = 1). Of the 100 analyzed cases, thirty-six (36 %) thyroid lymphoma cases were positive for t(3;14)/FOXP1-IGH. Thirty-three (55.9 %) of the 59 MALT lymphoma cases were positive for t(3;14)/FOXP1-IGH. Three (13.0 %) of the 23 DLBCL cases were positive for t(3;14)/FOXP1-IGH. All 4 follicular lymphomas examined were negative for t(3;14)/FOXP1-IGH. None of the benign cases was positive for t(3;14)/FOXP1-IGH, including Hashimoto's thyroiditis (0/13) and benign tissue (0/1). Our study found that t(3;14)/FOXP1-IGH was frequently found in thyroid MALT lymphoma. A detection of t(3;14)/FOXP1-IGH is ex...Continue Reading

References

Apr 1, 1985·European Journal of Cancer & Clinical Oncology·K AozasaA Sugimoto
Dec 1, 1973·British Medical Journal·M D Staunton, W P Greening
Jan 1, 1972·Cancer·C FreemanS J Cutler
Jan 1, 1996·Histopathology·R K Pedersen, N T Pedersen
May 9, 2000·The American Journal of Surgical Pathology·G A DerringerS L Abbondanzo
Apr 26, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Xavier SagaertChristiane De Wolf-Peeters
Jan 19, 2007·Leukemia·X SagaertM Baens
Nov 28, 2007·Journal of Clinical and Experimental Hematopathology : JCEH·Ming-Qing Du
May 20, 2008·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Alison GoatlyMing-Qing Du
Aug 12, 2009·Journal of Hematopathology·Sharathkumar BhagavathiWing C Chan
Sep 29, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Marion J J Kuper-HommelJ Han J M van Krieken
Nov 23, 2017·The Journal of Clinical Endocrinology and Metabolism·Natsuko WatanabeKoichi Ito

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