PMID: 6400435Apr 1, 1983Paper

T3b-T4 breast cancer: factors affecting results in combined modality treatments

Clinical & Experimental Metastasis
P ValagussaG Bonadonna

Abstract

Two hundred and seventy-seven consecutive patients with T3b-T4 breast cancer referred to the Milan Cancer Institute between 1973 and 1980 were treated with a combined modality approach. Chemotherapy (CT) consisted of AV, i.e. adriamycin (60-75 mg/m2 day 1) and vincristine (1.2 mg/m2 days 1 and 8) and was given for three to four cycles prior to local regional modality. Local-regional treatment consisted of either radiotherapy (RT) in 198 patients or surgery (S) in 79 women. Additional chemotherapy was then administered to a total of 205 patients. In the absence of distant metastases, frequency of good local control was significantly inferior in patients given CT + RT (63.9 per cent) compared to those treated with CT + RT + CT (75.4 per cent) and CT + S + CT (82.3 per cent, P = 0.033). Also freedom from progression (FFP) and overall survival (SURV) were significantly superior in the groups receiving more prolonged chemotherapy treatment compared to patients treated with CT + RT (FFP: P less than 0.0001; SURV: P = 0.002). None of the variables examined was able to affect the response rate, while axillary nodal status and tumor size played a major role in the duration of FFP and SURV. Our findings indicate that a more aggressive tr...Continue Reading

References

Jan 1, 1978·Cancer Chemotherapy and Pharmacology·M De LenaG Bonadonna
Jun 1, 1977·Cancer·M B LeveneS Hellman
Aug 1, 1977·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R D RubensJ L Hayward
Feb 19, 1976·The New England Journal of Medicine·G BonadonnaU Veronesi
Jan 1, 1973·The British Journal of Radiology·G H Fletcher
Jan 1, 1982·International Journal of Radiation Oncology, Biology, Physics·J BedwinekB Fineberg
Mar 1, 1980·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R D RubensJ L Hayward
Dec 1, 1943·Annals of Surgery·C D Haagensen, A P Stout

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Citations

Jan 1, 1996·Seminars in Surgical Oncology·H C Wang, S S Lo
Oct 8, 1999·Disease-a-month : DM·K FordB Lum
Apr 1, 1996·The Surgical Clinics of North America·K K HuntG N Hortobagyi
Dec 7, 2013·Current Treatment Options in Oncology·Bernardo L RapoportCarol A Benn
Jan 1, 1984·Breast Cancer Research and Treatment·G F Beadle, J R Harris
Jan 1, 1986·Breast Cancer Research and Treatment·R T ChlebowskiJ R Bateman
Jul 26, 2006·Acta Oncologica·Uwe GüthGad Singer
Oct 27, 2010·Thoracic Surgery Clinics·Massimiliano D'AiutoGaetano Rocco
Oct 1, 1985·International Journal of Radiation Oncology, Biology, Physics·C Schaake-KoningE Engelsman
Jan 1, 1988·International Journal of Radiation Oncology, Biology, Physics·J Boyages, A O Langlands
Mar 1, 1994·International Journal of Radiation Oncology, Biology, Physics·V AhernJ Boyages
May 15, 2007·The Surgical Clinics of North America·Marie Catherine Lee, Lisa A Newman
Mar 11, 2004·The Breast Journal·Arvid W J WielandRudi M H Roumen
Dec 25, 2009·The Breast Journal·Jasna But-HadzićVedran Hadzić
Jan 1, 1991·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J B DuboisH Pujol
May 14, 2008·Breast Cancer Research : BCR·Brian M NolenAnna E Lokshin
Jun 26, 2004·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·D LerougeJ Blondon
Apr 3, 2007·International Journal of Radiation Oncology, Biology, Physics·Verity AhernNicholas Wilcken
May 12, 2001·The Breast Journal·Robert W. Carlson, Anne M. Favret
Sep 15, 1987·Cancer·T SheldonJ R Harris
Nov 26, 2013·Current Opinion in Supportive and Palliative Care·Demetrios SimosCarmel Jacobs
Dec 6, 2003·The Oncologist·Sharon H Giordano
Feb 1, 1996·American Journal of Clinical Oncology·M ZambettiG Bonadonna
Oct 23, 2019·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Eunice López-MuñozNormand García-Hernández
Oct 15, 1987·International Journal of Cancer. Journal International Du Cancer·P F ConteC Monzeglio
Dec 30, 1998·Annals of Surgical Oncology·K I Bland
Dec 3, 2020·Breast Cancer : Targets and Therapy·Supreeth Kumar Reddy KunnuruBalaji Singh K
Mar 9, 2021·Taiwanese Journal of Obstetrics & Gynecology·Cervantes-Díaz María Teresa de JesúsLópez-Muñoz Eunice

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