TACE with degradable starch microspheres (DSM-TACE) as second-line treatment in HCC patients dismissing or ineligible for sorafenib

European Radiology
R IezziHepatocatt Study Group

Abstract

To date, there is no approved second-line treatment for patients dismissing sorafenib or ineligible for this treatment, so it would be useful to find an effective alternative treatment option. The aim of our study was to evaluate safety, feasibility and effectiveness of transarterial chemoembolisation with degradable starch microspheres (DSM-TACE) in the treatment of patients with advanced hepatocellular carcinoma (HCC) dismissing or ineligible for multikinase-inhibitor chemotherapy administration (sorafenib) due to unbearable side effects or clinical contraindications. Forty consecutive BCLC stage B or C patients (31 male; age, 70.6 ± 13.6 years), with intermediate or locally advanced HCC dismissing or ineligible for sorafenib administration, who underwent DSM-TACE treatment cycle via lobar approach were prospectively enrolled. Tumour response was evaluated on multidetector computed tomography based on mRECIST criteria. Primary endpoints were safety, tolerance and overall disease control (ODC); secondary endpoints were progression-free survival (PFS) and overall survival (OS). Technical success was achieved in all patients. No intra/peri-procedural death/major complications occurred. No signs of liver failure or systemic toxic...Continue Reading

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Citations

Apr 3, 2020·Cardiovascular and Interventional Radiology·Nigel HackingSachin Modi
Sep 19, 2019·World Journal of Gastroenterology : WJG·Riccardo InchingoloStavros Spiliopoulos
Oct 4, 2020·European Radiology·Luc Defreyne
Jul 29, 2021·Euroasian Journal of Hepato-gastroenterology·Aimun RaeesWasim Jafri
Aug 24, 2021·Nuclear Medicine and Molecular Imaging·Aysheh AlrfoohSandeep Laroia
Oct 26, 2021·Cardiovascular and Interventional Radiology·Pierleone LucatelliThomas Helmberger

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