Tachycardia, orthostatic hypotension and profound weakness due to concomitant use of fluoxetine and nifedipine

Pharmacopsychiatry
T L Azaz-Livshits, H D Danenberg

Abstract

The use of the selective serotonin reuptake inhibitor fluoxetine is associated with only minor cardiovascular effects. However, due to a possible inhibitory effect on the metabolism of calcium channel blockers it may potentiate the activity of nifedipine, causing profound adverse cardiovascular effects. This report describes the appearance of profound weakness, orthostatic hypotension and tachycardia following the initiation of fluoxetine treatment in a nifedipine-treated 80-year-old patient.

Citations

Apr 17, 2004·Clinical Pharmacokinetics·Catherine C Crone, Geoffrey M Gabriel
Jul 19, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sheldon Preskorn, Steve Werder
Apr 2, 2005·Journal of Psychiatric Practice·Sheldon H Preskorn
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Jan 24, 2002·The Journal of Pharmacology and Experimental Therapeutics·Dierk ThomasJohann Kiehn
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Feb 2, 2019·International Journal of Psychiatry in Clinical Practice·Siegfried Kasper

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