Tachykinin-1 in the central nervous system regulates adiposity in rodents

Endocrinology
Chitrang TrivediDiego Perez-Tilve

Abstract

Ghrelin is a circulating hormone that targets the central nervous system to regulate feeding and adiposity. The best-characterized neural system that mediates the effects of ghrelin on energy balance involves the activation of neuropeptide Y/agouti-related peptide neurons, expressed exclusively in the arcuate nucleus of the hypothalamus. However, ghrelin receptors are expressed in other neuronal populations involved in the control of energy balance. We combined laser capture microdissection of several nuclei of the central nervous system expressing the ghrelin receptor (GH secretagoge receptor) with microarray gene expression analysis to identify additional neuronal systems involved in the control of central nervous system-ghrelin action. We identified tachykinin-1 (Tac1) as a gene negatively regulated by ghrelin in the hypothalamus. Furthermore, we identified neuropeptide k as the TAC1-derived peptide with more prominent activity, inducing negative energy balance when delivered directly into the brain. Conversely, loss of Tac1 expression enhances the effectiveness of ghrelin promoting fat mass gain both in male and in female mice and increases the susceptibility to diet-induced obesity in ovariectomized mice. Taken together, o...Continue Reading

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Aug 5, 2017·International Journal of Obesity : Journal of the International Association for the Study of Obesity·C A MaguireV M Navarro
Aug 14, 2019·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Jinxin WangMark A Cline

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