PMID: 7539864Jul 1, 1995Paper

Tachykinin effects on bladder activity in conscious normal rats

The Journal of Urology
O IshizukaK E Andersson

Abstract

When instilled intravesically in normal, unanesthetized rats, neurokinin A (NKA), but not substance P (SP) and neurokinin B (NKB), stimulated micturition. The effect of NKA was inhibited by the NK2 receptor selective antagonists SR 48,968 and MEN 10,627, but not by the NK1 receptor selective antagonist RP 67,580, suggesting that the effect was mediated by stimulation of NK2 receptors. Given intra-arterially near the bladder, NKA produced an increase in basal intravesical pressure before initiating micturition, indicating that the tachykinin had a direct contractant effect on the detrusor smooth muscle. Such a contractile effect was not observed when NKA was given intravesically. The effect of intra-arterial NKA could not be blocked by the NK1 receptor selective antagonist SR 140,333 or the NK2 receptor selective antagonist SR 48,968, but by their combination. Also intra-arterial NKB stimulated micturition, but was less potent than NKA. Intra-arterial SP had only weak stimulating effects. The results suggest that intravesically administered NKA can initiate micturition in the normal rat by stimulation of superficially located NK2 receptors in the urothelium. Intra-arterially administered NKA caused bladder hyperactivity via stim...Continue Reading

References

Jan 1, 1992·Naunyn-Schmiedeberg's Archives of Pharmacology·P L van GiersbergenS H Buck
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Citations

May 15, 2002·Urology·Karl-Erik Andersson
Dec 21, 2002·Urology·Karl-Erik Andersson, Petter Hedlund
Jul 14, 1997·Journal of the Autonomic Nervous System·P Callsen-Cencic, S Mense
Aug 23, 2001·Autonomic Neuroscience : Basic & Clinical·A LecciC A Maggi
Jan 25, 2008·American Journal of Physiology. Renal Physiology·Bikramjit ChopraLori A Birder
Nov 18, 2003·BJU International·L TemplemanR Chess-Williams
Oct 25, 2016·Experimental Neurology·Beatrice GirardMargaret A Vizzard
Sep 3, 2004·Clinics in Geriatric Medicine·Rafi Kevorkian
Jun 14, 2018·American Journal of Physiology. Renal Physiology·Luke GrundyDavid Grundy
Dec 17, 2004·Pharmacological Reviews·Karl-Erik Andersson, Alan J Wein

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