PMID: 9437739Jan 23, 1998Paper

Tachykinin neuropeptide-evoked intracellular calcium transients in cultured guinea pig myenteric neurons

Peptides
G A SarosiM W Mulholland

Abstract

Substance P and related tachykinins are present in the mammalian gut and act as neurotransmitters. Microfluorimetric measurement of intracellular calcium ([Ca2+]i) was used to study tachykinin-sensitive myenteric neurons. Substance P (0.001-10 microM) evoked concentration-dependent increases in percentage of neurons responding (6-75%) and delta [Ca2+]i (88 +/- 24 to 212 +/- 16 nM). Neurokinin A (0.001-1 microM) produced similar responses. Removal of extracellular Ca2+ abolished substance P-induced Ca2+ signals, as did the addition of the Ca2+ channel blockers lanthanum chloride (5 mM) and nickel chloride (2.5 mM). Both nifedipine (1-50 microM) and diltiazem (1-50 microM) inhibited substance P-evoked Ca2+ responses in a dose-dependent manner. Substance P and related tachykinins evoke Ca2+ signaling in cultured myenteric neurons by the influx of extracellular Ca2+ through L and N-type plasma membrane Ca2+ channels.

References

Jul 1, 1990·The American Journal of Physiology·G MatthijsG Vantrappen
Nov 13, 1990·European Journal of Biochemistry·K TsuchidaS Nakanishi
Jan 1, 1991·Annals of the New York Academy of Sciences·S GuardS P Watson
Nov 23, 1987·Neuroscience Letters·J J GalliganR A North
Sep 1, 1995·General Pharmacology·C A Maggi
Aug 1, 1995·Surgery·B C Kimball, M W Mulholland
Jan 22, 1993·Regulatory Peptides·N P GerardC Gerard
Jan 1, 1993·Journal of Neuroscience Research·D L BroussardD Pleasure

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Citations

Jul 20, 2001·Archives of Insect Biochemistry and Physiology·S M Rankin, S M Seymour
Dec 4, 2003·Current Opinion in Pharmacology·Terence K SmithPieter Vanden Berghe
Apr 20, 2000·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·P Vanden BergheJ Janssens
Apr 27, 2002·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A De LaetJ-P Timmermans
Apr 7, 2004·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J Tack, T K Smith
Jan 13, 2010·Molecular and Biochemical Parasitology·Sreekanth PuttacharyRichard J Martin
May 16, 2002·Reviews in the Neurosciences·Markus Heilig, Annika Thorsell
Oct 29, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·P Vanden BergheJ Janssens
Jan 24, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Giovanni SarnelliJan Tack
Jun 22, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·P vanden BergheJ Janssens
Apr 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·C Kumaran, K Shivakumar

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