PMID: 7538136Feb 1, 1995Paper

Tachykinin NK1 and NK2 receptors mediate the non-cholinergic bronchospastic response to capsaicin and vagal stimulation in guinea-pigs

Journal of Autonomic Pharmacology
P BoniS Evangelista

Abstract

1. The antibronchospastic activity against acetylcholine, capsaicin, electrical vagal stimulation and the selective tachykinin agonists ([beta Ala8]NKA-(4-10) and [Sar9]SP sulfone) of a novel NK2 receptor antagonist, MEN10,627 and/or the known NK1 receptor antagonist (+/-)-CP96,345 was studied in anaesthetized guinea-pigs. 2. MEN10,627 (0.1 mumol kg-1 i.v.) and (+/-)-CP96,345 (3 mumol kg-1 i.v.) selectively reduced the bronchospasm induced by NK2 and NK1 tachykinin receptor agonists, respectively, without affecting the other tachykinin receptor agonist- or acetylcholine-induced bronchospastic response. 3. MEN10,627 (0.1 mumol kg-1 i.v.), in a dose-dependent manner, reduced the non-cholinergic response induced by bilateral stimulation of the vagi or by intravenous capsaicin. 4. The administration of (+/-)-CP96,345 (3 mumol kg-1 i.v.) alone did not affect these responses but, when administered in association with the NK2 antagonist, (+/-)-CP96,345, was able to potentiate its inhibitory effect. 5. It is concluded that both NK1 and NK2 receptors are involved in the non-cholinergic bronchoconstriction induced by capsaicin or by stimulation of the vagi, although the NK2 receptor contribution is prominent.

References

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Jul 1, 1987·Neuropeptides·G DrapeauD Regoli
May 1, 1989·Peptides·P RoveroA Giachetti
Jan 1, 1988·Life Sciences·S H Buck, S A Shatzer
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Feb 1, 1993·Journal of Autonomic Pharmacology·C A MaggiA Giachetti

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Citations

Apr 27, 2000·Allergy·G F JoosR A Pauwels
Apr 24, 2001·American Journal of Respiratory and Critical Care Medicine·S AmadesiP Geppetti
Jul 30, 2004·American Journal of Veterinary Research·Changaram S VenugopalEarnestine P Holmes
Mar 27, 2003·Autonomic & Autacoid Pharmacology·S KrishnakumarC S Venugopal
Oct 26, 2000·Neuropeptides·A LecciC A Maggi

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