Tachykinin NK1 receptor antagonists enhance stress-induced c-fos in rat locus coeruleus

European Journal of Pharmacology
M K Hahn, M J Bannon

Abstract

These experiments tested the hypothesis that substance P neurotransmission at tachykinin NK1 receptors in the locus coeruleus is involved in stress-induced activation of the locus coeruleus, using c-fos as an index of activation. Selective tachykinin NK1 receptor antagonists administered systemically did not result in substantial locus coeruleus c-fos expression. Restraint stress resulted in a large number of locus coeruleus c-fos expressing cells. Administration of two selective tachykinin NK1 receptor antagonists prior to restraint resulted in an increase in the number of locus coeruleus c-fos expressing cells, compared to restraint alone. These results suggest that the enhanced c-fos expression observed in response to tachykinin NK1 receptor antagonists combined with stress, could be due to the blockade of tachykinin NK1 receptor-mediated activity at sites other than the locus coeruleus, resulting in an overall activation of the locus coeruleus.

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Citations

Sep 20, 2007·Naunyn-Schmiedeberg's Archives of Pharmacology·Karl Ebner, Nicolas Singewald
Mar 27, 2001·Annual Review of Pharmacology and Toxicology·S C StoutC B Nemeroff
Oct 22, 2008·European Journal of Pharmacology·Nasser Haddjeri, Pierre Blier
Jan 22, 2005·European Journal of Pharmacology·Liliane J DablehJames L Henry
Dec 17, 2008·Annals of the New York Academy of Sciences·Karl EbnerNicolas Singewald
Dec 4, 2013·Expert Opinion on Therapeutic Targets·Kanwaljit Chopra, Vipin Arora
Mar 1, 2001·Stress : the International Journal on the Biology of Stress·M S Harbuz, D S Jessop

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