Tachykinin NK2 receptors predominantly mediate tachykinin-induced contractions in ovine trachea

European Journal of Pharmacology
A M ReynoldsR Scicchitano

Abstract

In vitro studies were conducted to characterize the contractile effects of tachykinins in normal ovine trachea with a view in the future to compare tachykinin contractile responses in allergic tissue. Tracheal smooth muscle strips were prepared for in vitro studies of isometric contraction in response to cumulative addition of carbachol, acetylcholine, histamine, neuropeptide gamma, substance P, neurokinin A, neurokinin B, [Sar9, Met(O2)11]substance P, [Nle10]neurokinin A-(4-10), and [Succinyl-Asp6, Me-Phe8]substance P-(6-11) (senktide). The rank order of potency was neuropeptide gamma > carbachol > neurokinin A > or = [Nle10]neurokinin A-(4-10) > acetylcholine > or = histamine. Phosphoramidon enhanced the contractile response to neurokinin A and substance P, but not to neuropeptide gamma, [Sar9, Met(O2)11]substance P or senktide. Repeated cumulative concentration responses for acetylcholine, substance P, neurokinin A, [Sar9, Met(O2)11]substance P and histamine were also conducted to test for tachyphylaxis. No tachyphylaxis to acetylcholine, substance P, or neurokinin A was observed, however, [Sar9, Met(O2)11]substance P and histamine did exhibit tachyphylaxis. Atropine had no effect on tracheal contractions to neurokinin A and...Continue Reading

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Citations

Jul 14, 2000·Respirology : Official Journal of the Asian Pacific Society of Respirology·A M ReynoldsR Scicchitano
Jun 26, 2001·Respirology : Official Journal of the Asian Pacific Society of Respirology·A J RiceR Scicchitano
Jun 23, 2005·Journal of Biomedical Science·Yi-Ruu LinMing-Huan Chan
May 8, 2018·The Journal of Pharmacology and Experimental Therapeutics·Nadia M J RupniakEdward C Burgard
Jun 5, 2002·Journal of Peptide Science : an Official Publication of the European Peptide Society·Sylwia Rodziewicz-MotowidłoKrzysztof Rolka

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