Tachykinins and central respiratory activity: an in vitro study on the newborn rat

European Journal of Pharmacology
Roger MonteauGérard Hilaire

Abstract

The newborn rat brainstem-spinal cord preparation was used to study the effects of tachykinins on the activity of the respiratory rhythm generator in vitro and to characterize the receptors involve. Substance P and tachykinin NK1 and NK3 receptor agonists induced a concentration-dependent increase in the respiratory frequency (10(-9)-10(-7) M), whereas the respiratory frequency was only slightly affected by the tachykinin NK2 receptor agonist. Pre-treatments with tachykinin NK1 receptor antagonists (SR140333, (S)1-¿2-[3-(3.4-dichlorophenyl) -1-(3-isopropoxyphenylacetyl)piperidin-n-3-yl]ethyl¿-4-ph eny l-1-azoniabicyclo [2,2,2]octane chloride; GR82334, pGlu-Ala- Asp-Pro-Asn-Lys-Phe-Tyr-(S-S)Pro-Leu(spiro-gamma-lactam)-Trp-NH2) reduced the substance P-induced increases in the respiratory frequency but the tachykinin NK2 receptor antagonist (SR48968, ((S)-N-methyl-N-[4-4-acetylamino-4-phenylpiperidine)-2-(3,4-dichlorop hen yl) butyl]benzamide); MEN 10376, Asp-Tyr-D-Trp-Val-D-Trp-Lys-NH2) had no effect; the increase in the respiratory frequency induced by the tachykinin NK3 receptor agonist was not affected by a pre-treatment with tachykinin NK1 and NK2 receptor antagonists. These result indicate that tachykinin NK1 and NK3 recepto...Continue Reading

References

Feb 1, 1990·Journal of Applied Physiology·Z B ChenT Hedner
Jan 1, 1991·Annual Review of Neuroscience·S Nakanishi
Jul 1, 1985·Acta Physiologica Scandinavica·Y Yamamoto, H Lagercrantz
Nov 1, 1985·Journal of the Autonomic Nervous System·A G LeibsteinR Pauschert
Aug 15, 1986·Neuroscience Letters·N LindeforsU Ungerstedt
Jan 12, 1987·Life Sciences·D RegoliP D'Orléans-Juste
Jul 1, 1987·Neuropeptides·G DrapeauD Regoli
May 1, 1989·Peptides·P RoveroA Giachetti
Jul 21, 1971·Nature: New Biology·M M ChangH D Niall
Apr 1, 1993·Physiological Reviews·M Otsuka, K Yoshioka
Sep 17, 1993·Brain Research·O RampinM Denavit-Saubié
Feb 1, 1993·The Journal of Physiology·A D Lindsay, J L Feldman
Feb 1, 1993·Journal of Autonomic Pharmacology·C A MaggiA Giachetti
May 18, 1956·Acta Physiologica Scandinavica·U S VON EULER, B PERNOW
Jun 6, 1931·The Journal of Physiology·U S V Euler, J H Gaddum

❮ Previous
Next ❯

Citations

May 13, 1999·Brain Research. Developmental Brain Research·K PtakR Monteau
Jun 14, 2000·Progress in Neurobiology·K BallanyiI Homma
Aug 28, 1999·Neuroscience Letters·K Ptak, G Hilaire
Jul 11, 2002·Respiratory Physiology & Neurobiology·Immanuela Ravé Moss, André Laferrière
Jun 18, 2003·Respiratory Physiology & Neurobiology·Ganesh K Kumar, Nanduri R Prabhakar
Jul 23, 2003·Respiratory Physiology & Neurobiology·Qi-Jian SunPaul M Pilowsky
May 21, 2004·Nature Reviews. Neuroscience·George B Richerson
Jan 29, 2000·The European Journal of Neuroscience·K PtakR Monteau
Dec 21, 2002·The European Journal of Neuroscience·Krzysztof PtakGérard Hilaire
Jul 11, 2006·The Journal of Physiology·Angelina Y Fong, Jeffrey T Potts
Dec 24, 2015·Sleep Medicine Reviews·Melissa C LipfordRayleigh Ping-Ying Chiang
Jul 8, 2008·Respiratory Physiology & Neurobiology·Atsushi Doi, Jan-Marino Ramirez
Sep 18, 2007·Respiratory Physiology & Neurobiology·Hartmut GrasemannGeorge T De Sanctis
Apr 3, 2003·The European Journal of Neuroscience·Jean-Charles ViemariGérard Hilaire
Jun 17, 2008·The European Journal of Neuroscience·Fulvia BongianniTito Pantaleo
Oct 18, 2006·The European Journal of Neuroscience·Y N Shvarev, H Lagercrantz
Apr 28, 2004·Respiratory Physiology & Neurobiology·H Ronny WickströmHugo Lagercrantz
Jan 16, 2004·The Journal of Physiology·Consuelo Morgado-Valle, Jack L Feldman
Apr 6, 2007·Zhurnal evoliutsionnoĭ biokhimii i fiziologii·A V Bursian
Dec 7, 2007·Journal of Neurophysiology·Angelina Y Fong, Jeffrey T Potts
Oct 16, 2012·Journal of Applied Physiology·J BernerR Wickstrom
Apr 30, 1999·Physiological Reviews·G Hilaire, B Duron
Jan 12, 2021·Journal of Neurophysiology·Thiago S MoreiraAna C Takakura
Sep 4, 2007·The Journal of Experimental Biology·Jean-Claude Le MévelJ Michael Conlon

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.