PMID: 7545233Jun 1, 1995Paper

Tachykinins as mediators of slow EPSPs in guinea-pig gall-bladder ganglia: involvement of neurokinin-3 receptors

The Journal of Physiology
G M Mawe

Abstract

1. The effects of endogenous tachykinins and related peptides on intact guinea-pig gall-bladder neurones were investigated with single-electrode voltage- and current-clamp recording techniques. 2. Pressure ejection of substance P (100 microM) caused a long lasting membrane depolarization that was associated with a decrease in input resistance. In cells that were voltage-clamped to their resting membrane potential, substance P activated an inward current. 3. The reversal potentials of the substance P-induced depolarization and inward current were congruent to 0 mV. In a low-Na+ solution, the substance P-induced depolarization and inward current were reduced in amplitude. 4. Substance P increased the excitability of neurones, as evidenced by a greater anodal break activity and an increase in the number of action potentials generated during a depolarizing current pulse. 5. Substance P, neurokinin A (NKA) and neurokinin B (NKB) were applied by superfusion to determine the relative potencies of these tachykinins. NKB was the most potent, with an EC50 of 24 nM. The EC50 values for NKA and substance P were 47.8 and 281 nM, respectively. 6. The neurokinin-3 (NK-3) receptor agonist senktide depolarized neurones with an EC50 of 6.3 nM. N...Continue Reading

Citations

Apr 8, 1998·The American Journal of Physiology·L J Jennings, G M Mawe
May 20, 1999·The Journal of Physiology·M NeunlistM Schemann
Jun 8, 2001·News in Physiological Sciences : an International Journal of Physiology Produced Jointly by the International Union of Physiological Sciences and the American Physiological Society·Gary M. Mawe
Jul 9, 2003·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A C B MeedeniyaG T P Saccone
Mar 1, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·D P PooleJ B Furness
Dec 31, 1997·The American Journal of Physiology·W MacNaughtonS Vanner
Jul 18, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Brendan J CanningAllen C Myers
Aug 29, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·J M HemmingG M Mawe
Jul 12, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·B P Manning, G M Mawe
Nov 14, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·L ZhangD B Hoover
Jul 9, 1998·American Journal of Respiratory and Critical Care Medicine·S DaouiC Advenier
Apr 17, 2004·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A D ShaftonJ B Furness
Sep 24, 2004·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Onesmo B BalembaGary M Mawe
Jul 21, 2000·Alimentary Pharmacology & Therapeutics·E A Shaffer
May 6, 2016·Frontiers in Immunology·Andrea I LoewendorfMike Harrington
Mar 3, 2004·British Journal of Pharmacology·Céline RougetCharles Advenier

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