Tachykinins as transmitters of ascending contractile component of the peristaltic reflex.

The American Journal of Physiology
John R Grider

Abstract

The role of tachykinin neurons of the myenteric plexus in the regulation of the intestinal peristaltic reflex was examined in rat colonic segments that enable separate measurement of ascending contraction and descending relaxation. Release of immunoreactive substance P (SP) and substance K (SK) increased (68% for SP; 70% for SK) during ascending contraction and decreased (37% for SP; 13% for SK) during descending relaxation. Exogenous SP and SK augmented ascending contraction and inhibited descending relaxation. Neither SP antiserum nor SK antiserum had any effect on descending relaxation. The antisera had no effect also on ascending contraction induced by low grades of stretch (2 g), but they inhibited significantly contraction induced by high grades (6-10 g) of stretch (52 +/- 8% inhibition with SP antiserum and 48 +/- 8% with SK antiserum). A combination of both antisera abolished ascending contraction induced by high grades of stretch. Atropine inhibited only partially ascending contraction at high grades of stretch. The pattern of inhibition by both antisera and by atropine implied that ascending contraction induced by high grades of stretch was mediated by tachykinin neurons acting directly on smooth muscle cells as well ...Continue Reading

Citations

Jan 25, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·L OnoriM Tonini
Apr 10, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·J R Grider
Apr 5, 2014·American Journal of Physiology. Gastrointestinal and Liver Physiology·Cuiping LiPankaj Jay Pasricha
Aug 16, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·John R Grider, Lea E Langdon
Aug 15, 2019·American Journal of Physiology. Gastrointestinal and Liver Physiology·Alberto L Perez-Medina, James J Galligan
Mar 28, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Luciano OnoriMarcello Tonini
Jul 11, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·John R GriderBilly R Martin
Sep 2, 2006·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Hiroki Itoh
Aug 29, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·D A Schneider, J J Galligan
Sep 30, 2016·Toxins·Raffaela PeroFrancesca Lembo
Aug 7, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·John R Grider

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