PMID: 9437710Jan 1, 1997Paper

Tachykinins may mediate capsaicin-induced, but not vagally induced motility in porcine antrum

Peptides
P T SchmidtJ J Holst

Abstract

Tachykinins are thought to be involved in extrinsic control of motility in the gastrointestinal tract. Using the isolated perfused porcine antrum with intact vagal innervation, we studied the effects of substance P, neurokinin A and capsaicin infusion, and electrical stimulation of the vagus nerves on antral motility without or with infusion of non-peptide antagonists for NK-1 receptors (CP96345) and NK-2 receptors (SR48968). Substance P and neurokinin A stimulated antral motility in a dose-dependent manner. The effect could be inhibited by atropine or a combination of the NK-1 and NK-2 receptor antagonists. Electrical stimulation of the vagus nerves and infusion of capsaicin (10(-5) M) stimulated antral motility. Vagally induced motility was not influenced by infusion of CP96345 and SR48968, whereas the effect of capsaicin was blocked. We conclude that tachykinins may be involved in regulation of antral motility through sensory nerves in the porcine antrum, but they do not seem to be involved in vagal regulation of antral motility.

References

Oct 1, 1978·Naunyn-Schmiedeberg's Archives of Pharmacology·L Barthó, J Szolcsányi
Oct 1, 1979·Naunyn-Schmiedeberg's Archives of Pharmacology·J Szolcsányi, L Barthó
May 15, 1992·Biochemical and Biophysical Research Communications·C AdvenierD Regoli
Sep 4, 1992·European Journal of Pharmacology·A W SchmidtJ Heym
Jan 25, 1991·Science·R M SniderR W Spencer
Jan 1, 1987·British Journal of Pharmacology·U Holzer-PetscheH Seitz
Dec 1, 1989·Neuroscience Research·K FunakoshiR Kishida
Jun 1, 1982·Naunyn-Schmiedeberg's Archives of Pharmacology·L A Chahl
Feb 1, 1982·Acta Physiologica Scandinavica·P LidbergH Ahlman
Jun 29, 1981·Brain Research·F Cervero, H A McRitchie
Jun 1, 1993·Journal of Neurochemistry·C J MussapE Burcher
Oct 1, 1996·Gastroenterology·P SchmidtJ J Holst

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Citations

Mar 31, 2006·Langenbeck's Archives of Surgery·Mario H MuellerMartin E Kreis
Aug 10, 2001·Regulatory Peptides·K TornøeJ J Holst
Mar 22, 2003·Autonomic Neuroscience : Basic & Clinical·Linda YipAlison M J Buchan
Apr 20, 2006·Critical Reviews in Food Science and Nutrition·M N Satyanarayana
Sep 29, 2001·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·T N RasmussenJ J Holst
Oct 6, 2011·Regulatory Peptides·Takenori OnagaHideaki Hayashi
Aug 27, 2003·Journal of Pharmacological Sciences·Akiyoshi SomeyaToshihiko Murayama

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