PMID: 2496085Mar 1, 1989Paper

Tachykinins mediate bronchoconstriction elicited by isocapnic hyperpnea in guinea pigs

Journal of Applied Physiology
D W RayJ Solway

Abstract

We tested the hypothesis that tachykinins mediate hyperpnea-induced bronchoconstriction (HIB) in 28 guinea pigs. Stimulus-response curves to increasing minute ventilation with dry gas were generated in animals depleted of tachykinins by capsaicin pretreatment and in animals pretreated with phosphoramidon, a neutral metalloendopeptidase inhibitor. Sixteen anesthetized guinea pigs received capsaicin (50 mg/kg sc) after aminophylline (10 mg/kg ip) and terbutaline (0.1 mg/kg sc). An additional 12 animals received saline (1 ml sc) instead of capsaicin. One week later, all animals were anesthetized, given propranolol (1 mg/kg iv), and mechanically ventilated (6 ml/kg, 60 breaths/min, 50% O2 in air fully water saturated). Phosphoramidon (0.5 mg iv) was administered to five of the noncapsaicin-treated guinea pigs. Eucapnic dry gas (95% O2-5% CO2) hyperpnea "challenges" were performed by increasing the tidal volume (2-6 ml) and frequency (150 breaths/min) for 5 min. Capsaicin-pretreated animals showed marked attenuation in HIB, with a rightward shift of the stimulus-response curve compared with controls; the estimated tidal volume required to elicit a twofold increase in respiratory system resistance (ES200) was 5.0 ml for capsaicin-pre...Continue Reading

Citations

Feb 17, 2001·American Journal of Respiratory and Critical Care Medicine·C KotaruE R McFadden
Jan 1, 1992·The American Review of Respiratory Disease·A M ReynoldsR D McEvoy
Mar 15, 2001·Journal of Applied Physiology·O E Suman, K C Beck
Jul 1, 1990·The American Review of Respiratory Disease·L B PlissB Pichurko
Feb 8, 2003·American Journal of Respiratory and Critical Care Medicine·Arthur N FreedRyoichi Suzuki
Aug 1, 1993·The American Review of Respiratory Disease·T R HsiueJ Solway
Jul 1, 1992·The American Review of Respiratory Disease·T R HsiueJ Solway
Aug 18, 2001·Journal of Applied Physiology·T D MickleboroughL Cordain
Jan 14, 1999·Journal of Applied Physiology·X X YangJ G Martin
Aug 7, 2021·Autonomic Neuroscience : Basic & Clinical·Hyun Jin Jung, Ronny Priefer

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