PMID: 8613631Mar 1, 1996Paper

Tachykinins mediate the potentiation of antigen-induced bronchoconstriction by cold air in guinea pigs

The Journal of Allergy and Clinical Immunology
S YoshiharaJ A Nadel

Abstract

The role of tachykinins in the potentiation of antigen-evoked bronchoconstriction induced by inhalation of cold air was studied in guinea pigs. Cold air was delivered through a tracheal cannula to anesthetized, artificially ventilated guinea pigs sensitized with ovalbumin and pretreated with atropine (1.4 micromol/kg). Inhalation of cold air increased total pulmonary resistance (RL) in a time-dependent manner; inhalation of cold air for 10 or 15 minutes, but not for 5 minutes, produced a significant increase in RL. Aerosolized ovalbumin (5 breaths) increased RL in a dose-dependent manner (0.5% to 5%). Inhalation of cold air for 5 minutes significantly enhanced both the peak and the duration of the increase in RL induced by 0.5% ovalbumin. The tachykinin neurokinin 2-receptor antagonist, SR 48968 (0.3 micromol/kg intravenously) inhibited both the peak and the duration of the bronchoconstriction induced by 5-minute inhalation of cold air and ovalbumin (0.5%), whereas it did not affect the response to ovalbumin (0.5%) alone. These findings suggest that exposure to cold air potentiates the bronchoconstriction response to antigen and that this potentiation is mediated by tachykinin release from sensory nerves.

Citations

Oct 1, 1996·General Pharmacology·A Lindén
Jun 19, 2004·International Archives of Allergy and Immunology·Osamu MukaiyamaMakoto Yamashita
Mar 1, 2008·BJU International·Pierangelo GeppettiSilvia Benemei
Jun 7, 2012·Expert Opinion on Therapeutic Patents·Delia PretiRiccardo Patacchini
Oct 3, 2002·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·P Holzer
Sep 25, 2007·Cephalalgia : an International Journal of Headache·P NicolettiL A Pini
Dec 23, 2003·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Branka GruborMark R Ackermann
Apr 10, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·B D'AgostinoF Rossi
Oct 29, 2008·American Journal of Rhinology·Ching-Yin HoYu Ru Kou
Mar 27, 2003·Autonomic & Autacoid Pharmacology·S KrishnakumarC S Venugopal

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