PMID: 9437709Jan 1, 1997Paper

Tachykinins (substance P, neurokinin A and neuropeptide gamma) and neurotensin from the intestine of the Burmese python, Python molurus

Peptides
J M ConlonS M Secor

Abstract

Peptides with substance P-like immunoreactivity, neurokinin A-like immunoreactivity and neurotensin-like immunoreactivity were isolated in pure form from an extract of the intestine of the Burmese python (Python molurus). The primary structure of python substance P (Arg-Pro-Arg-Pro-Gln-Gln-Phe-Tyr-Gly-Leu- Met-NH2) shows one amino acid substitution (Phe8-->Tyr) compared with chicken/alligator substance P and an additional substitution (Lys3-->Arg) as compared with mammalian substance P. The neurokinin A-like immunoreactivity was separated into two components. Python neuropeptide gamma (Asp-Ala-Gly-Tyr- Ser-Pro-Leu-Ser-His-Lys-Arg-His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met-NH2 shows three substitutions (Gly5-->Ser, Gln6-->Pro and Ile7-->Leu) compared with alligator neuropeptide gamma and an additional substitution (His4-->Tyr) compared with mammalian neuropeptide gamma. Python neurokinin A (His-Lys-Thr-Asp-Ser-Phe-Val-Gly- Leu-Met.NH2) is identical to human/chicken/alligator neurokinin A. Python neurotensin (pGlu-Leu-Val-His-Asn-Lys-Ala-Arg-Pro-Tyr-Ile-Leu) is identical to chicken/alligator neurotensin. The data are indicative of differential evolutionary pressure to conserve the amino acid sequences of reptilian gastrointestinal p...Continue Reading

References

Mar 5, 1992·Regulatory Peptides·C ShawK D Buchanan
May 31, 1991·Biochemical and Biophysical Research Communications·H KozawaH Matsuo
Feb 1, 1988·Regulatory Peptides·J M ConlonL Thim
Nov 1, 1989·General and Comparative Endocrinology·R Perez-TomasJ M Polak
May 1, 1987·Archivum Histologicum Japonicum = Nihon Soshikigaku Kiroku·J YamadaN Yanaihara
Sep 1, 1993·Peptides·A Rodriguez-BelloJ M Conlon

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Citations

Apr 8, 2011·Journal of the American Society for Mass Spectrometry·Xiaojuan LiCheng Lin
Oct 12, 2001·Brain Research Bulletin·S Holmgren, J Jensen
Nov 22, 2002·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Anna HolmbergSusanne Holmgren
Mar 20, 2010·BMC Developmental Biology·Birger ScholzLennart Dencker
Nov 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·S M SecorT E Adrian
Sep 11, 2010·Physiology & Behavior·Torben P NielsenTobias Wang
May 14, 2005·Annals of the New York Academy of Sciences·F SicardC Delarue
Mar 21, 2012·The Journal of Comparative Neurology·Satoshi OgawaIshwar S Parhar
Feb 22, 2005·Regulatory Peptides·Nini SkovgaardTobias Wang
May 22, 2009·Annals of the New York Academy of Sciences·Jong-Ik HwangJae Young Seong
Oct 28, 1998·Nature·S M Secor, J Diamond
Oct 22, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Stephen M SecorJared Diamond
Jun 15, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Nini SkovgaardTobias Wang
Aug 12, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·T WangJ M Conlon
Apr 8, 1998·The Journal of Peptide Research : Official Journal of the American Peptide Society·J M ConlonE Burcher
Jul 27, 2005·Peptides·Lu Liu, Elizabeth Burcher
Dec 29, 2009·Behavioural Brain Research·Kristóf LászlóLászló Lénárd

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