PMID: 6166795Mar 1, 1981Paper

Tachyphylaxis to 5-hydroxytryptamine in perfused kidneys from spontaneously hypertensive and normotensive rats

Journal of Cardiovascular Pharmacology
M G Collis, P M Vanhoutte

Abstract

Isolated perfused kidneys from 4- to 6-month-old spontaneously hypertensive rats (SHR, Japanese strain) exhibit increased "vascular reactivity" to 5-hydroxytryptamine (5-HT) and a slower rate of development of tachyphylaxis to this substance when compared with kidneys from normotensive Wistar-Kyoto (WKY) rats. We investigated the possibility that the reduced rate of development of tachyphylaxis could be related to a interaction of 5-HT with adrenergic mechanisms or with endogenous 5-HT. Tachyphylaxis was induced by repeated administration of 5-HT to kidneys from SHR and WKY rats. This procedure did not affect vasoconstrictor responses evoked by norepinephrine. The development of tachypylaxis to 5-HT in kidneys from SHR and WKY rats was not changed by chemical sympathectomy with 6-hydroxydopamine. Treatment of SHR with para-chlorophenylalanine did not affect their blood pressure or the development of tachyphylaxis to 5-HT. These results indicate that delayed tachyphylaxis to 5-HT in kidneys of SHR is not due to an interference with adrenergic mechanisms and does not depend on endogenous 5-HT levels. The phenomenon represents an unusual modification of vascular smooth muscle exposed to chronic high pressure, but it is unlikely th...Continue Reading

Citations

Jun 1, 1985·Naunyn-Schmiedeberg's Archives of Pharmacology·A PetterssonB Persson
Jan 1, 1990·Clinical and Experimental Hypertension. Part A, Theory and Practice·K SudhirJ A Angus
Sep 1, 1983·Cephalalgia : an International Journal of Headache·F SicuteriB Anselmi
Sep 1, 1983·Cephalalgia : an International Journal of Headache·F Sicuteri
Apr 16, 2005·Clinical Science·Stephanie W Watts
Jul 1, 1986·The British Journal of Ophthalmology·X MartinC Gailloud
Jul 1, 1982·The Journal of Pharmacy and Pharmacology·B PerssonM Henning

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