Tachyphylaxis to beta-adrenoceptor agonists in guinea pig airway smooth muscle in vivo and in vitro

European Journal of Pharmacology
J S DouglasA Bouhuys

Abstract

Beta-Adrenoceptor tachyphylaxis was induced by incubating spirally cut guinea pig tracheas with isoproterenol (2.4 x 10(-7) M) for 20 min. This incubation reduced the relaxant effects of catecholamines but not of dibutyryl cyclic AMP, theophylline or sodium nitrite. Tracheas incubated with norepinephrine, phosphodiesterase inhibitors or cyclic nucleotides became tachyphylactic to isoproterenol. Pretreatment with indomethacin prevented induction of tachyphylaxis. Incubation with adenosine, methoxamine or sodium nitrite did not induce beta-adrenoceptor tachyphylaxis. When we gave isoproterenol intramuscularly to guinea pigs, airway sensitivity to aerosolized histamine was unchanged but the toxicity of parenterally administered histamine was increased. A prolonged treatment with isoproterenol reduced airway sensitivity to histamine aerosols; this reduced sensitivity was reversed by indomethacin. Thus, beta-adrenoceptor tachyphylaxis may not explain increased toxicity of parenteral histamine after isoproterenol treatment. Elevated levels of cyclic AMP and an increased synthesis of prostaglandins may result in diminished response to beta-receptor stimulation.

References

Apr 1, 1976·European Journal of Pharmacology·B Spilker, J Tyll
Jan 8, 1972·Lancet·H Herxheimer
Nov 10, 1971·Nature: New Biology·G E DaviesA R Somerville
Jan 1, 1972·Naunyn-Schmiedeberg's Archives of Pharmacology·U Klotz, K Stock
Oct 1, 1972·Journal of Pharmaceutical Sciences·I WeinrybS M Hess
Dec 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·J StonerM Vaughan
Apr 22, 1974·Biochimica Et Biophysica Acta·F Murad, H Kimura
Jan 6, 1968·Nature·W J Sweatman, H O Collier
Nov 1, 1967·British Journal of Pharmacology and Chemotherapy·H O Schild
Dec 30, 1972·British Medical Journal·H Herxheimer
Jan 27, 1973·British Medical Journal·A A MathéN Svanborg
Jun 1, 1973·The Journal of Allergy and Clinical Immunology·V PopaA Bouhuys
Jan 1, 1974·Clinical Pharmacology and Therapeutics·C T DolleryS R Walker
Mar 1, 1974·British Journal of Pharmacology·D G McDevittJ G Swanton
Feb 1, 1971·Archives of Environmental Health·C F ReinhardtL S Mullin
Feb 10, 1968·British Medical Journal·F E SpeizerL B Strang
May 1, 1969·British Journal of Pharmacology·J M CollinsJ G Swanton
Oct 1, 1964·British Journal of Pharmacology and Chemotherapy·J R VANE
Jun 1, 1965·The Journal of Pharmacy and Pharmacology·J W CONSTANTINE

❮ Previous
Next ❯

Citations

Oct 1, 1996·Pediatric Pulmonology·G J OmlorC M Schramm
Aug 1, 1979·Naunyn-Schmiedeberg's Archives of Pharmacology·W H AndersonA Szentivanyi
Nov 1, 1986·Naunyn-Schmiedeberg's Archives of Pharmacology·R LindmarJ Sandmann
Sep 1, 1982·Naunyn-Schmiedeberg's Archives of Pharmacology·A J SchreursF P Nijkamp
Oct 1, 1987·Agents and Actions·M E ZacourJ G Martin
Oct 1, 1984·Agents and Actions·A J Schreurs, F P Nijkamp
May 21, 1982·European Journal of Pharmacology·A J LewisM E Rosenthale
Jan 21, 1983·European Journal of Pharmacology·U BretzU M Ney
Apr 8, 1983·European Journal of Pharmacology·J C WilliamsR E Giles
Jan 15, 1985·European Journal of Pharmacology·P G Duncan, J S Douglas
May 15, 1990·Mechanisms of Ageing and Development·P B Davis, P J Byard
May 1, 1981·Journal of Pharmacological Methods·R M O'NeilF R Goodman
Dec 1, 1993·Pharmacology & Therapeutics·M J Connolly
Jan 1, 1982·International Journal of Immunopharmacology·W J WieczorekE S Assem
Dec 4, 2002·European Journal of Pharmacology·Jaap OostendorpKnut Biber
Jul 1, 1992·Pharmacology & Toxicology·A BergendalC G Löfdahl
Oct 1, 1987·The American Review of Respiratory Disease·J S Douglas, C Brink
Apr 22, 1983·European Journal of Pharmacology·M P AbbracchioC Omini
Jan 1, 1989·Pulmonary Pharmacology·L DaffonchioC Omini
Nov 1, 1984·Medical Hypotheses·J Lieb, A Balter
Dec 1, 1995·Biopharmaceutics & Drug Disposition·H OhtaniT Iga
Jan 1, 1982·Progress in Clinical and Biological Research·M Villalón, P Verdugo
Jan 1, 1988·Fundamental & Clinical Pharmacology·J FichelleC Advenier
Feb 1, 1983·Biological Reviews of the Cambridge Philosophical Society·S Løvtrup
May 10, 2005·Bulletin of Entomological Research·J R BellG S Weyman
Oct 9, 2003·The Journal of Peptide Research : Official Journal of the American Peptide Society·S C MottaC R Nakaie
May 1, 1983·British Journal of Industrial Medicine·E ZuskinJ S Douglas
May 1, 1978·Acta Pharmacologica Et Toxicologica·S R Johansson, R G Anderson
Mar 1, 1982·The Journal of Pharmacy and Pharmacology·C BrinkJ S Douglas
Jul 1, 1980·Acta Pharmacologica Et Toxicologica·S R Johansson, R G Andersson
Jan 1, 1979·Acta Pharmacologica Et Toxicologica·R G Andersson, S R Johansson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.