Tackling a novel lethal virus: a focus on H7N9 vaccine development

Expert Review of Vaccines
Irina Isakova-Sivak, Larisa Rudenko

Abstract

Avian-origin H7N9 influenza viruses first detected in humans in China in 2013 continue to cause severe human infections with a mortality rate close to 40%. These viruses are acknowledged as the subtype most likely to cause the next influenza pandemic. Areas covered: Here we review published data on the development of H7N9 influenza vaccine candidates and their evaluation in preclinical and clinical trials identified on PubMed database with the term 'H7N9 influenza vaccine'. In addition, a search with the same term was done on ClinicalTrials.gov to find ongoing clinical trials with H7N9 vaccines. Expert commentary: Influenza vaccines are the most powerful tool for protecting the human population from influenza infections, both seasonal and pandemic. During the past four years, a large number of promising H7N9 influenza vaccine candidates have been generated using traditional and advanced gene engineering techniques. In addition, with the support of WHO's GAP program, influenza vaccine production capacities have been established in a number of vulnerable low- and middle-income countries with a high population density, allowing the countries to be independent of vaccine supply from high-income countries. Overall, it is believed th...Continue Reading

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Citations

Jul 21, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Claire M TullyTeresa Lambe
Apr 17, 2021·Frontiers of Medicine·William J LiuYingxia Liu

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