Tackling a weighty problem

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Tackling a weighty problem

Abstract

References

Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice

Genetic mapping of a gene causing hypertension in the stroke-prone spontaneously hypertensive rat.

Genetic analysis of autoimmune type 1 diabetes mellitus in mice

The syntenic relationship between the critical deletion region for the Prader-Willi/Angelman syndromes and proximal mouse chromosome 7

Molecular mapping of the mouse ob mutation

Molecular mapping of obesity genes

Rat obesity gene fatty (fa) maps to chromosome 5: evidence for homology with the mouse gene diabetes (db)

Molecular characterization of a region of DNA associated with mutations at the agouti locus in the mouse

Epidemiological correlates of NIDDM in Hispanics, whites, and blacks in the U.S. population

Molecular mapping of the mouse db mutation.

Human glucose-6-phosphate dehydrogenase gene carried on a yeast artificial chromosome encodes active enzyme in monkey cells

Role of set-point theory in regulation of body weight

The body-mass index of twins who have been reared apart

Expression of a myelin basic protein gene in transgenic shiverer mice: correction of the dysmyelinating phenotype

Central corticotropin-releasing factor administration prevents the excessive body weight gain of genetically obese (fa/fa) rats

Mapping mendelian factors underlying quantitative traits using RFLP linkage maps.

The genetics of diabetes susceptibility in mice

1989 McCollum Award lecture. Genetic and hypothalamic mechanisms for obesity--finding the needle in the haystack

Experimental obesity: a homeostatic failure due to defective nutrient stimulation of the sympathetic nervous system

The regulation of food intake by peptides.

Genetic imprinting suggested by maternal heterodisomy in nondeletion Prader-Willi syndrome.

Genetic organization of the agouti region of the mouse.

Familial dependence of the resting metabolic rate

Prenatal determination of obesity, tumor susceptibility, and coat color pattern in viable yellow (Avy/a) mice. The yellow mouse syndrome

Prevalence of diabetes and impaired glucose tolerance and plasma glucose levels in U.S. population aged 20-74 yr

The regulation of body weight

Effects of parabiosis of obese with diabetes and normal mice

Further delineation of the Cohen syndrome; report on chorioretinal dystrophy, leukopenia and consanguinity

Citations

A role for leptin in hemopoieses?

Long-term and rapid regulation of ob mRNA levels in adipose tissue from normal (Sprague Dawley rats) and obese (db/db mice, fa/fa rats) rodents

Triacylglycerol biosynthetic enzymes in lean and obese Zucker rats

The agouti gene: turned on to yellow

Regulation of adipose maturation and energy homeostasis

Leptin and OB-R: body weight regulation by a cytokine receptor

Chewing the fat

Overexpression of the obese (ob) gene in adipose tissue of human obese subjects

Increased obese mRNA expression in omental fat cells from massively obese humans

Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action

How can drug addiction help us understand obesity?

Expression studies of key adipogenic transcriptional factors reveal that the anti-adipogenic properties of retinol in primary cultured human preadipocytes are due to retinol per se

A molecular model for the genetic and phenotypic characteristics of the mouse lethal yellow (Ay) mutation

Regulated expression of the obese gene product (leptin) in white adipose tissue and 3T3-L1 adipocytes

The adipocyte specific transcription factor C/EBPalpha modulates human ob gene expression

OB protein binds specifically to the choroid plexus of mice and rats

Transcriptional activation of the mouse obese (ob) gene by CCAAT/enhancer binding protein alpha

The leptin era: new insight into the mechanisms of body weight homeostasis

Genetic aspects of obesity

Transgenic mouse models of disease: altering adipose tissue function in vivo

Adipocyte differentiation and leptin expression

Central role of ceramide biosynthesis in body weight regulation, energy metabolism, and the metabolic syndrome.

Weighing in on the lean genes

Evidence against either a premature stop codon or the absence of obese gene mRNA in human obesity

Endotoxin and cytokines induce expression of leptin, the ob gene product, in hamsters

Thiazolidinediones repress ob gene expression in rodents via activation of peroxisome proliferator-activated receptor gamma

Dissimilarity in Fos and Jun immunoreactivity in hypothalamic regions between obese and lean Zucker rats

TNF-alpha is required for the attraction of mesenchymal precursors to white adipose tissue in Ob/ob mice.

Obese gene expression at in vivo levels by fat pads derived from s.c. implanted 3T3-F442A preadipocytes

NAG-1/GDF-15 prevents obesity by increasing thermogenesis, lipolysis and oxidative metabolism

Leptin as an important link between obesity and cardiovascular risk factors in men with acute myocardial infarction

Leptin, a neuroendocrine mediator of immune responses, inflammation, and sickness behaviors

Targeted disruption of the melanocortin-4 receptor results in obesity in mice

Molecular characterization of the mouse agouti locus

The molecular basis of the obese mutation in ob2J mice

FoxO1 negatively regulates leptin-induced POMC transcription through its direct interaction with STAT3.

Genetic models of obesity and energy balance in the mouse

Effects of pioglitazone hydrochloride on Japanese patients with type 2 diabetes mellitus

Leptin-dependent platelet aggregation and arterial thrombosis suggests a mechanism for atherothrombotic disease in obesity

Considerations on genetic and environmental factors that contribute to resistance or sensitivity of mammals including humans to toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related compounds. Part 1: Genetic factors affecting the toxicity of TCDD

Differentiation-dependent expression of obese (ob) gene by preadipocytes and adipocytes in primary cultures of porcine stromal-vascular cells

Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice.

The adipocyte: storage depot or node on the energy information superhighway?

The rat corpulent (cp) mutation maps to the same interval on (Pgm1-Glut1) rat chromosome 5 as the fatty (fa) mutation

Genetic dissection of complex genetic factor involved in NIDDM of OLETF rat

Effects of pioglitazone on adipose tissue remodeling within the setting of obesity and insulin resistance

A new paradigm for the understanding of obesity: the role of stem cells

Strategies for the molecular genetic analysis of obesity in humans