Tackling bioactive glass excessive in vitro bioreactivity: Preconditioning approaches for cell culture tests

Acta Biomaterialia
Francesca E CiraldoAldo R Boccaccini

Abstract

Bioactive glasses (BGs) are being increasingly considered for biomedical applications in bone and soft tissue replacement approaches thanks to their ability to form strong bonding with tissues. However, due to their high reactivity once in contact with water-based solutions BGs rapidly exchange ions with the surrounding environment leading in most cases to an undesired increase of the pH under static in vitro conditions (due to alkaline ion "burst release"), making difficult or even impossible to perform cell culture studies. Several pre-conditioning treatments have been therefore proposed in laboratories worldwide to limit this problem. This paper presents an overview of the different strategies that have been put forward to pre-treat BG samples to tackle the pH raise issue in order to enable cell biology studies. The paper also discusses the relevant criteria that determine the selection of the optimal pre-treatment depending on the BG composition and morphology (e.g. particles, scaffolds). Bioactive glasses (BGs), since their discovery in 1971 by L.L Hench, have been widely used for bone replacement and repair, and, more recently, they are becoming highly attractive for bone and soft tissue engineering applications. BGs have...Continue Reading

Citations

Dec 19, 2019·Journal of Tissue Engineering and Regenerative Medicine·Amirhossein MoghanianNasim Annabi
Mar 4, 2020·International Journal of Molecular Sciences·Fabian WesthauserAldo R Boccaccini
Mar 7, 2020·Journal of Biomedical Materials Research. Part a·Elnaz TamjidMaryam Nikkhah
Apr 11, 2020·Journal of Biomedical Materials Research. Part a·Fabian WesthauserAldo R Boccaccini
May 14, 2020·Methods and Protocols·Frederike HohenbildFabian Westhauser
Jan 17, 2019·International Journal of Molecular Sciences·Maria KaradjianFabian Westhauser
May 1, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marcela Martín-Del-CampoLuis Rojo
Apr 16, 2020·Materials·Devis BellucciValeria Cannillo
Feb 7, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Mani DibaSander C G Leeuwenburgh
Feb 7, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Roger BorgesJuliana Marchi
Apr 5, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Chitra S, Balakumar S
Feb 23, 2020·International Journal of Biological Macromolecules·Bhisham Narayan SinghPradeep Srivastava
Apr 20, 2019·International Journal of Biological Macromolecules·Bhisham Narayan SinghPradeep Srivastava
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Arturo E Aguilar-RabielaAldo R Boccaccini
Apr 12, 2019·Journal of Colloid and Interface Science·Breno R BarrioniMarivalda de M Pereira

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