Tackling formalin-fixed, paraffin-embedded tumor tissue with next-generation sequencing

Cancer Discovery
Christopher L Corless, Paul T Spellman

Abstract

Most tumor samples available for clinical genotyping are formalin-fixed and paraffin-embedded (FFPE), but there has been relatively little published on the suitability of such samples for next-generation sequencing approaches. A new study by Wagle and colleagues shows that a combination of hybridization-capture and deep sequencing yields high-quality data from FFPE specimens.

References

Nov 20, 2009·PloS One·Laura E MacConaillLevi A Garraway
Apr 21, 2011·JAMA : the Journal of the American Medical Association·John S WelchRichard K Wilson
Jul 6, 2011·The Journal of Molecular Diagnostics : JMD·Carol BeadlingChristopher L Corless

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Citations

Dec 1, 2012·Archives of Pathology & Laboratory Medicine·Philip T Cagle, Timothy Craig Allen
Sep 12, 2015·The Journal of Molecular Diagnostics : JMD·Lotte N J MoensJohan Botling
Jul 30, 2015·PloS One·Danielle Mercatante CarrickSheri D Schully
Feb 23, 2019·Carcinogenesis·Sagarika BanerjeeErle S Robertson
Apr 17, 2018·Briefings in Bioinformatics·Lan ZhaoMaarten F Bijlsma
Dec 18, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Fiamma ButtittaAntonio Marchetti

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