Tackling HIV and AIDS: contributions by non-human primate models

Lab Animal
Koen K A Van Rompay

Abstract

During the past three decades, non-human primate (NHP) models have gained an increasing importance in HIV basic and translational research. In contrast to natural host models, infection of macaques with virulent simian or simian-human immunodeficiency viruses (SIV, SHIV) results in a disease that closely resembles HIV infection and AIDS. Although there is no perfect animal model, and each of the available models has its benefits and limitations, carefully designed NHP studies with selection of experimental variables have unraveled important questions of basic pathogenesis and have provided the tools to explore and screen intervention strategies. For example, NHP studies have advanced our understanding of the crucial events during early infection, and have provided proof-of-concept of antiretroviral drug treatment and prevention strategies such as pre-exposure prophylaxis (PrEP) regimes that are increasingly used worldwide, and upon overcoming further barriers of implementation, have the potential to make the next generation AIDS-free. Remaining goals include the pursuit of an effective HIV vaccine, and HIV cure strategies that would allow HIV-infected people to ultimately stop taking antiretroviral drugs. Through a reiterative ...Continue Reading

References

Jun 7, 1985·Science·M D DanielR C Desrosiers
Aug 29, 1995·Proceedings of the National Academy of Sciences of the United States of America·K UberlaB Oberg
Aug 1, 1995·Proceedings of the National Academy of Sciences of the United States of America·P A LuciwC Cheng-Mayer
Apr 1, 1994·AIDS Research and Human Retroviruses·T W BabaR M Ruprecht
May 2, 1998·The Veterinary Journal·K Hartmann
May 21, 1998·The Journal of Infectious Diseases·K K Van RompayM L Marthas
Sep 16, 2000·Trends in Microbiology·B M NathJ D Boyer
Apr 25, 2001·The Journal of Infectious Diseases·W HuangJ Mellors
Sep 23, 2003·Journal of Medical Primatology·M B Gardner
Jan 15, 2004·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Philippe GaillardUNKNOWN Ghent IAS Working Group on HIV in Women and Children
Feb 27, 2004·Nature Immunology·Dennis R BurtonRichard T Wyatt
Apr 29, 2004·Journal of Virology·Koen K A Van RompayNorbert Bischofberger

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Citations

Dec 12, 2017·ILAR Journal·Ronald S Veazey, Andrew A Lackner
Dec 1, 2017·Open Mind : Discoveries in Cognitive Science·Katrina FerraraBarbara Landau
Feb 26, 2021·The Journal of Clinical Investigation·Afam A OkoyeLouis J Picker
Apr 20, 2021·Frontiers in Immunology·Shawn Abeynaike, Silke Paust

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Methods Mentioned

BETA
biopsy

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