Tackling influenza with broadly neutralizing antibodies

Current Opinion in Virology
Davide CortiAntonio Lanzavecchia

Abstract

Monoclonal antibodies have revolutionized the treatment of several human diseases, including cancer, autoimmunity and inflammatory conditions and represent a new frontier for the treatment of infectious diseases. In the last decade, new methods have allowed the efficient interrogation of the human antibody repertoire from influenza immune individuals and the isolation of several monoclonal antibodies capable of dealing with the high variability of influenza viruses. Here, we will provide a comprehensive overview of the specificity, antiviral and immunological mechanisms of action and development into the clinic of broadly reactive monoclonal antibodies against influenza A and B viruses.

Citations

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Methods Mentioned

BETA
electron microscopy
X-ray

Clinical Trials Mentioned

NCT01406418
NCT02371668
NCT01756950
NCT01938352
NCT02071914
NCT01992276
NCT02045472
NCT02468115
NCT01877785
NCT02284607

Software Mentioned

ISIRV

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