Tackling non-metastatic castration-resistant prostate cancer: special considerations in treatment

Expert Review of Anticancer Therapy
Archana Anantharaman, Eric J Small

Abstract

Prostate cancer (PCa) is currently the second most common cancer affecting men worldwide. Metastatic castration-resistant prostate cancer (mCRPC) is the incurable form of PCa, carrying the poorest prognosis, and can develop from non-metastatic CRPC (M0 CRPC). CRPC is defined as progression of the disease with castrate level testosterone levels, achieved with primary androgen deprivation therapy (ADT). M0 CRPC is a highly heterogeneous disease process lacking clear standard of care therapies. Areas covered: In this review, a broad literature search was undertaken to explore data available for therapeutic options and guidelines in the management of M0 CRPC. Expert commentary: While there are compelling data for various therapeutics for the treatment of M0 CRPC, no clear standard of care is apparent at this time. Furthermore, technological advances in imaging may have a significant impact on this future of this disease state.

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Feb 6, 2018·Scientific Reports·Massimiliano RuscicaMonica Gomaraschi
Oct 17, 2019·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·G RovielloE Mini
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Mar 10, 2021·Expert Review of Clinical Pharmacology·Valeria Emma PalmieriRoberta Giorgione

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