Abstract
Nonulosonic acids, commonly referred to as sialic acids, are a highly important group of nine-carbon sugars common to all domains of life. They all share biosynthetic and structural features, but otherwise display a remarkable chemical diversity. In humans, sialic acids cover all cells which makes them important for processes such as cellular protection, immunity and brain development. On the other hand, sialic acids and other nonulosonic acids have been associated with pathological processes including cancer and viral infections. In prokaryotes, nonulosonic acids are commonly associated with pathogens, which developed through molecular mimicry a strategy to circumvent the host's immune response. However, the remarkably large chemical diversity of prokaryotic nonulosonic acids challenges their discovery, and research on molecular characteristics essential for medical applications are often not feasible. Here, we demonstrate a novel, universal large-scale discovery approach that tackles the unmapped diversity of prokaryotic nonulosonic acids. Thereby, we utilize selective chemical labelling combined with a newly established mass spectrometric all-ion-reaction scanning approach to identify nonulosonic acids and other ulosonic aci...Continue Reading
References
Apr 25, 1986·Journal of Chromatography·S HaraY Ohkura
Apr 1, 1997·Glycobiology·A KleinA E Manzi
Aug 2, 2001·Glycobiology·J P ZanettaR Schauer
Oct 24, 2001·Biochemistry·C L JacobsC R Bertozzi
Feb 14, 2002·Chemical Reviews·Takashi Angata, Ajit Varki
Oct 1, 1963·Comparative Biochemistry and Physiology·L WARREN
Jan 15, 2004·Advances in Carbohydrate Chemistry and Biochemistry·Yuriy A KnirelUlrich Zãhringer
Jun 22, 2005·Proceedings of the National Academy of Sciences of the United States of America·Che-Chang HsuChi-Huey Wong
Jan 6, 2006·Planta·Reinhard ZelenyFriedrich Altmann
Feb 7, 2009·Blood·Aaron F CarlinAjit Varki
Aug 12, 2009·Proceedings of the National Academy of Sciences of the United States of America·Amanda L LewisAjit Varki
Aug 24, 2010·Omics : a Journal of Integrative Biology·Miriam Cohen, Ajit Varki
Oct 12, 2010·Journal of Dental Research·G SekotC Schäffer
Sep 5, 2012·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·R LouwenA van Belkum
Jan 5, 2014·Biochemistry·Michael J Morrison, Barbara Imperiali
Mar 13, 2014·FEMS Microbiology Reviews·Britt Koskella, Michael A Brockhurst
Jan 18, 2015·Glycobiology·Johanna J KenyonRuth M Hall
Feb 11, 2015·Journal of the American Chemical Society·Stefan MatthiesPeter H Seeberger
Sep 26, 2015·PloS One·Eric MorelloShaynoor Dramsi
Nov 1, 2016·Journal of the American Society for Mass Spectrometry·Alexandra C Schrimpe-RutledgeJohn A McLean
Nov 20, 2016·Proceedings of the National Academy of Sciences of the United States of America·Justin Johan Jozias van der HooftSimon Rogers
Oct 29, 2017·Cellular and Molecular Life Sciences : CMLS·Abu Iftiaf Md Salah Ud-Din, Anna Roujeinikova
Aug 21, 2018·Chemical Science·Diane Dayoung ParkCarlito B Lebrilla
Sep 2, 2018·The Journal of Biological Chemistry·Ben A WagstaffRobert A Field
Dec 5, 2018·Advances in Carbohydrate Chemistry and Biochemistry·Roland Schauer, Johannis P Kamerling
Oct 8, 2019·Chemical Science·Diana Catalina Palacio LozanoMark P Barrow
Citations
Oct 9, 2020·Extremophiles : Life Under Extreme Conditions·Samuel I de JongDuncan G G McMillan
Apr 2, 2021·Applied Microbiology and Biotechnology·Sergio Tomás-MartínezYuemei Lin
Jul 16, 2021·Journal of Proteome Research·Xiaoyu YangStephen E Stein
Aug 4, 2021·The ISME Journal·Martin PabstMichele Laureni
Apr 2, 2020·Environmental Science & Technology·Marissa BoleijYuemei Lin