Tackling the increasing complexity of CF care

Pediatric Pulmonology
Gregory S Sawicki, Christopher H Goss

Abstract

Health outcomes for individuals with cystic fibrosis (CF) have dramatically improved in parallel with better organization of clinical care systems, evolution of novel therapeutics, and improvements in diagnosis and screening for CF and CF-related complications. In parallel with these advances has come an increasing complexity and burden of care, leading to challenges with adherence to treatment regimens. As novel therapeutics continue to be developed and introduced to the CF care regimen, there are clear opportunities to refine and personalize care. This can be done by adding comparative effectiveness research to the CF clinical research paradigm and integrating novel technologies in drug delivery and remote monitoring that can facilitate adherence but also reduce the burden of treatment while maintaining efficacy. This review highlights both the challenges of the increasingly complex treatment regimens in CF and the opportunities to advance care by addressing adherence, implementation science, comparative effectiveness, and integration of novel technologies in CF care.

References

Jan 1, 1992·Pediatric Pulmonology·S M FinkelsteinW J Warwick
Jan 1, 1993·The Journal of Pediatrics·S C FitzSimmons
Sep 4, 1999·American Journal of Public Health·R E GlasgowS M Boles
Apr 12, 2002·Pediatric Pulmonology·Yvonne Bastian-LeePaul Seddon
Oct 3, 2002·The European Respiratory Journal·M E HodsonJ R W Govan
Sep 25, 2003·JAMA : the Journal of the American Medical Association·Sean R TunisCarolyn M Clancy
Oct 7, 2004·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Judith A BurrowsScott C Bell
Jan 13, 2006·Journal of Pediatric Psychology·Avani C Modi, Alexandra L Quittner
Mar 25, 2006·American Journal of Respiratory and Critical Care Medicine·Ian M Balfour-LynnUNKNOWN CF WISE (Withdrawal of Inhaled Steroids Evaluation) Investigators
May 9, 2006·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Avani C ModiAlexandra L Quittner
Sep 1, 2007·American Journal of Respiratory and Critical Care Medicine·Patrick A FlumeUNKNOWN Cystic Fibrosis Foundation, Pulmonary Therapies Committee
Jul 29, 2008·American Journal of Respiratory and Critical Care Medicine·Karen S McCoyA Bruce Montgomery
Oct 28, 2008·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Gregory S SawickiWalter M Robinson
Apr 8, 2009·Journal of Clinical Epidemiology·Kevin E ThorpeKalipso Chalkidou
Apr 18, 2009·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Kevin E ThorpeKalipso Chalkidou
Jul 2, 2009·Annals of Internal Medicine·Harold C Sox, Sheldon Greenfield
Jul 21, 2010·Journal of Telemedicine and Telecare·Gianluigi GrzincichSerena Quattrucci
Oct 5, 2010·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Warren LenneyJohn M Kovarik
Oct 22, 2010·Pediatric Pulmonology·Michael W KonstanGerhild Angyalosi
Nov 16, 2010·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Michael W KonstanDavid E Geller
Nov 19, 2010·The New England Journal of Medicine·Frank J AccursoBonnie W Ramsey
Jan 22, 2011·BMC Pulmonary Medicine·Becky A BriesacherLynne M Quittell
Mar 3, 2011·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Allan L CoatesMartin Charron
Mar 9, 2011·Pediatric Pulmonology·Tanja BesierUNKNOWN TIDES Study Group
Mar 15, 2011·Journal of Aerosol Medicine and Pulmonary Drug Delivery·David E GellerSilvia Heuerding
Apr 5, 2011·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Michelle N EakinKristin A Riekert
Apr 19, 2011·American Journal of Respiratory and Critical Care Medicine·Christopher H Goss
Apr 19, 2011·American Journal of Respiratory and Critical Care Medicine·Jerry A Krishnan
Sep 7, 2011·Archives of Pediatrics & Adolescent Medicine·Miriam M TreggiariUNKNOWN Early Pseudomonas Infection Control (EPIC) Investigators
Oct 14, 2011·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Alexandra L QuittnerMichael W Konstan
Apr 3, 2012·Pediatric Pulmonology·Gregory S Sawicki, Harm Tiddens
Sep 19, 2012·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Baroukh M AssaelUNKNOWN AZLI Active Comparator Study Group
Jan 29, 2013·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Gregory S SawickiUNKNOWN Investigators and Coordinators of the Epidemiologic Study of Cystic Fibrosis
Apr 2, 2013·American Journal of Respiratory and Critical Care Medicine·Peter J MogayzelUNKNOWN Pulmonary Clinical Practice Guidelines Committee
Jun 28, 2013·Annals of the American Thoracic Society·Rhonda D VanDykeMichael Seid
Sep 3, 2013·The New England Journal of Medicine·Michael S Lauer, Ralph B D'Agostino
Feb 1, 2014·Chest·Alexandra L QuittnerKristin A Riekert
Mar 13, 2014·Pediatric Pulmonology·Gregory S SawickiWalter M Robinson

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Citations

Apr 14, 2016·Pediatric Pulmonology·Edith T ZemanickCharles R Esther
Apr 14, 2016·Journal of Medical Economics·Ellison D SuthoffJeffrey S Wagener
Sep 24, 2016·Pediatric Pulmonology·Cameron L JordanMarianna M Henry
Feb 20, 2018·Pediatric Pulmonology·Aarti ShakkottaiSamya Z Nasr
Mar 29, 2019·The Laryngoscope·Amanda G RuizJeremy D Prager
Jul 2, 2020·Journal of Clinical Nursing·Brandon M Varilek, Mary J Isaacson
Dec 7, 2016·BMC Pulmonary Medicine·Anjali Y BhagirathKangmin Duan
Feb 24, 2017·Global Pediatric Health·Aarti Shakkottai, Samya Z Nasr
Aug 7, 2017·Global Pediatric Health·Beverly FitzPatrickTiffany Lee
Feb 23, 2019·Journal of Clinical Psychology in Medical Settings·Christina J NicolaisAlexandra L Quittner
Mar 3, 2021·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Rosa CouckeUNKNOWN European Cystic Fibrosis Society-Clinical Trials Network Patient Advisory Group

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