PMID: 9527715Jan 1, 1997Paper

Tacrine

Revista de medicina de la Universidad de Navarra
C DávilaP de Castro

Abstract

Significant changes in cholinergic neurotransmission have been described in Alzheimer's disease (AD). These findings led to consider cholinergic deficit as the main disturbance in AD, due to degeneration of presynaptic cholinergic neurons, and that replacement of acetylcholine could restore the cognitive alterations characteristic of AD. Although it was soon demonstrated that cholinergic deficit was not the only change, cholinergic hypothesis has allowed to set several possible therapeutic strategies for these severe disease, the most promising is administration of acetylcholinesterase inhibitors. Of all the compounds investigated, tacrine (tetrahydroamineacridine) has shown in several clinical trials a positive effect on memory in patients with symptoms of slight to moderate severity. Although not all studies have given successful result, probably due to methodological differences, global clinical impression has justified the introduction of tacrine as the first palliative therapy in AD.

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Citations

Jan 18, 2007·Expert Opinion on Therapeutic Targets·Ulrike HolzgrabeEva Kugelmann
Apr 12, 2007·Expert Opinion on Pharmacotherapy·Rita MorettiGilberto Pizzolato
Feb 14, 2006·Toxicology in Vitro : an International Journal Published in Association with BIBRA·M J M EzoulinF Massicot
May 28, 2004·Expert Opinion on Pharmacotherapy·Rita MorettiAntonio Bava
Apr 1, 2003·Current Therapeutic Research, Clinical and Experimental·George T Grossberg
Feb 24, 2001·Journal of Psychopharmacology·N R DunnS A Shakir
Jun 3, 2005·Nature Reviews. Drug Discovery·Neil Kaplowitz
Jun 25, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Lian Yee YipEric Chun Yong Chan
Dec 29, 2000·Journal of the American Geriatrics Society·M M VerricoA L Towers
Dec 14, 2007·Pharmacogenetics and Genomics·Daniel F CarrB Kevin Park
Nov 16, 2007·Pharmacogenetics and Genomics·Ana AlfirevicMunir Pirmohamed
Jul 1, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Keith J MurphyCiaran M Regan

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