Tacrolimus 0.1% ointment: is it really effective in plasma cell vulvitis? Report of four cases

Dermatology : International Journal for Clinical and Investigative Dermatology
Annarosa VirgiliMonica Corazza

Abstract

Plasma cell vulvitis is a clinically and histologically well-characterized chronic disease that usually relapses after various topical therapies. Considering the inflammatory nature of the disease, the new topical calcineurin inhibitors have been also employed successfully in few cases of Zoon's balanitis, the corresponding male condition. The aim of our study is to evaluate the effectiveness of tacrolimus ointment in a small group of plasma cell vulvitis sufferers. 4 women affected by biopsy-proved plasma cell vulvitis were enrolled, after informed consent. The topical drug was applied twice daily for 6 weeks, then tapered on the basis of the clinical results. Symptoms and objective parameters were obtained periodically at the beginning, after 6 weeks and up to the end of the topical treatment. A final biopsy was performed in 3 out of our 4 patients. The follow-up is still ongoing. The comparative analysis of subjective, objective and histopathological data has shown discordant and less encouraging results than those reported for the corresponding male condition. At the moment, topical tacrolimus could be considered an alternative treatment for plasma cell vulvitis only in cases resistant to conventional therapies.

References

Jul 1, 1989·International Journal of Dermatology·M Pelisse
Jul 1, 1993·The British Journal of Dermatology·G M KavanaghC T Kennedy
Sep 5, 2002·The British Journal of Dermatology·G KirtschigT J Stoof
Jan 11, 2003·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·AnneMarie Neill, S Thornton
Jun 6, 2003·Journal of the American Academy of Dermatology·Till AssmannThomas Ruzicka
Jul 23, 2003·Archives of Dermatology·Rainer KunstfeldFranz M Karlhofer
Jul 23, 2003·Archives of Dermatology·Markus BöhmGisela Bonsmann
Sep 27, 2003·The British Journal of Dermatology·H L EeB H Ong
Jul 31, 2004·American Journal of Obstetrics and Gynecology·Jeffrey T JensenCatherine M Leclair
Nov 4, 2004·Journal of the American Academy of Dermatology·Mark LebwohlUNKNOWN Tacrolimus Ointment Study Group
Dec 22, 2004·Archives of Dermatology·Jorge Santos-JuanesJorge Soto
Apr 19, 2005·International Urogynecology Journal and Pelvic Floor Dysfunction·Sylvia M BotrosRoger P Goldberg
Jul 28, 2005·Clinical and Experimental Dermatology·B Hernandez-MachinB Hernandez
Nov 26, 2005·The British Journal of Dermatology·G A Moreno-AriasJ Palou-Almerich
Jul 11, 2006·BJOG : an International Journal of Obstetrics and Gynaecology·D M Luesley, G P Downey
Aug 12, 2006·Dermatology : International Journal for Clinical and Investigative Dermatology·Christian HafnerThomas Vogt
Oct 6, 2006·Expert Opinion on Pharmacotherapy·Uwe WollinaMohamed Badawy Abdel-Naser
Oct 13, 2006·Dermatology : International Journal for Clinical and Investigative Dermatology·Tarun NarangDavinder Parsad
Apr 27, 2007·Dermatology : International Journal for Clinical and Investigative Dermatology·David J MargolisWarren Bilker

❮ Previous
Next ❯

Citations

Dec 31, 2009·Journal of Lower Genital Tract Disease·Mahalakshmi GurumurthyMargaret Cruickshank
Mar 17, 2012·Indian Journal of Dermatology, Venereology and Leprology·Aygen ÇelikÜmit Özekici
Dec 20, 2011·Actas dermo-sifiliográficas·L Barchino-OrtizP Lázaro-Ochaita
Jun 1, 2010·Dermatologic Clinics·Andrew N Lin
Jul 26, 2014·Journal of the European Academy of Dermatology and Venereology : JEADV·A VirgiliM Corazza
Aug 10, 2011·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·E ToeimaL Igali
May 23, 2015·Journal of Cutaneous Pathology·May P Chan, Mary Jane Zimarowski
Sep 1, 2017·Journal of Lower Genital Tract Disease·July Jaimes SuarezYosmar Carolina Pérez-González
Aug 4, 2010·Pediatric Dermatology·Alexandra D McCollumLawrence F Eichenfield
Apr 23, 2019·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Genevieve Pourzan, Heather S Laird-Fick
Apr 26, 2019·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Bharti SharmaBishan D Radotra
Jun 28, 2017·Advances in Anatomic Pathology·Marc R LewinMaria A Selim
Sep 22, 2020·Seminars in Diagnostic Pathology·Sara C ShalinKatelynn K Campbell
Jun 5, 2021·Journal of Lower Genital Tract Disease·Jenny S W Yun, Emma Veysey
Jul 6, 2021·Journal of Lower Genital Tract Disease·Jill M KrapfAndrew T Goldstein

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Lower Genital Tract Disease
Jennifer Gunter, Loren Golitz
Dermatologic Clinics
Ruth Murphy
Obstetrics and Gynecology
Mindy LonginottiRaymond H Kaufman
© 2021 Meta ULC. All rights reserved