Tacrolimus: A Review of Laboratory Detection Methods and Indications for Use

Laboratory Medicine
Derick A Kalt

Abstract

Tacrolimus (Tac) is an immunosuppressive drug that is used in preventing organ and tissue rejection in patients after transplantation. Tac administration requires frequent and diligent monitoring by physicians to ensure proper dosage and to limit the potential for harmful adverse effects, which can include renal damage, neurotoxicity, and other serious adverse events. Tac is a calcineurin inhibitor, which suppresses the function of T-cells. Its success as an immunosuppressive agent has been well documented in preventing graft-vs-host disease in several types of organ transplants. This literature review will discuss Tac metabolism and its role in preventing tissue and organ transplant rejection. A variety of detection techniques used in the clinical laboratory, including dried-blood-spot analysis, liquid chromatography-tandem mass spectrometry, and immunoassay also will be discussed.

References

Oct 5, 2001·Expert Opinion on Pharmacotherapy·D Simpson
Mar 12, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Friedrich K PortRobert A Wolfe
Jan 15, 2009·Therapeutic Drug Monitoring·Shawn AmannDaniel M Levine
Mar 5, 2009·Therapeutic Drug Monitoring·Pierre WallemacqRainer W Schmid
Aug 3, 2010·Journal of Pharmaceutical and Biomedical Analysis·Christophe BazinAnne Hulin
Jan 15, 2014·Clinical Chemistry·Verena Gounden, Steven J Soldin
May 3, 2014·Therapeutic Drug Monitoring·Yash Pal AgrawalDaniel M Levine
Jan 2, 2016·Clinica Chimica Acta; International Journal of Clinical Chemistry·Adam J McShaneSihe Wang
Mar 11, 2017·World Journal of Transplantation·Gerold ThölkingStefan Reuter
Apr 5, 2017·Anticancer Research·Samah NassereddineImad Tabbara

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Citations

Apr 14, 2020·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Mustafa Gökhan ErtosunÖmer Özkan
Jun 25, 2020·Revista do Colégio Brasileiro de Cirurgiões·Lucas Soares BezerraPaulo Sérgio Vieira de Melo
Mar 19, 2021·Saudi Journal of Biological Sciences·Lijian ChenQiang Yin
Nov 6, 2020·Therapeutic Drug Monitoring·Nasrullah UndreIan Dawson
Sep 19, 2018·The Journal of Physical Chemistry. B·Maria Angélica C MassonThiago C Correra

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