Abstract
Tacrolimus (Tac) is an immunosuppressive drug that is used in preventing organ and tissue rejection in patients after transplantation. Tac administration requires frequent and diligent monitoring by physicians to ensure proper dosage and to limit the potential for harmful adverse effects, which can include renal damage, neurotoxicity, and other serious adverse events. Tac is a calcineurin inhibitor, which suppresses the function of T-cells. Its success as an immunosuppressive agent has been well documented in preventing graft-vs-host disease in several types of organ transplants. This literature review will discuss Tac metabolism and its role in preventing tissue and organ transplant rejection. A variety of detection techniques used in the clinical laboratory, including dried-blood-spot analysis, liquid chromatography-tandem mass spectrometry, and immunoassay also will be discussed.
References
Oct 5, 2001·Expert Opinion on Pharmacotherapy·D Simpson
Mar 12, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Friedrich K PortRobert A Wolfe
Jan 15, 2009·Therapeutic Drug Monitoring·Shawn AmannDaniel M Levine
Mar 5, 2009·Therapeutic Drug Monitoring·Pierre WallemacqRainer W Schmid
Jul 6, 2010·Clinical Biochemistry·Paul J TaylorPeter I Pillans
Aug 3, 2010·Journal of Pharmaceutical and Biomedical Analysis·Christophe BazinAnne Hulin
Sep 24, 2013·Talanta·Remco A KosterDonald R A Uges
Jan 15, 2014·Clinical Chemistry·Verena Gounden, Steven J Soldin
May 3, 2014·Therapeutic Drug Monitoring·Yash Pal AgrawalDaniel M Levine
Jan 2, 2016·Clinica Chimica Acta; International Journal of Clinical Chemistry·Adam J McShaneSihe Wang
Aug 9, 2016·Therapeutic Drug Monitoring·Anne-Sophie BargnouxJean-Paul Cristol
Mar 9, 2017·Leukemia Research·Lei GaoXi Zhang
Mar 11, 2017·World Journal of Transplantation·Gerold ThölkingStefan Reuter
Mar 17, 2017·Bioanalysis·Remco A KosterDaan J Touw
Apr 5, 2017·Anticancer Research·Samah NassereddineImad Tabbara
Apr 26, 2017·Rapid Communications in Mass Spectrometry : RCM·Elisa PolledriSilvia Fustinoni
Citations
Apr 14, 2020·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Mustafa Gökhan ErtosunÖmer Özkan
May 1, 2020·Bioanalysis·Manuel ÁlvarezSonia Sentellas
Jun 11, 2019·Pharmaceutical Development and Technology·Chun TaoHongtao Song
Apr 9, 2020·Frontiers in Oncology·Qi ZhouDong Shang
Jun 20, 2018·The Journal of Biological Chemistry·Guangdong LuHaibin Shi
Feb 26, 2019·Transplantation·Marlotte A A van der VeerSarwa Darwish Murad
Sep 26, 2020·Frontiers in Pharmacology·Rongrong WangTingbo Liang
Jun 25, 2020·Revista do Colégio Brasileiro de Cirurgiões·Lucas Soares BezerraPaulo Sérgio Vieira de Melo
Mar 19, 2021·Saudi Journal of Biological Sciences·Lijian ChenQiang Yin
Nov 6, 2020·Therapeutic Drug Monitoring·Nasrullah UndreIan Dawson
Dec 6, 2020·Therapeutic Drug Monitoring·Nasrullah UndreImran Hussain
Aug 8, 2021·The Annals of Pharmacotherapy·Yuting HeBin Huang
Sep 19, 2018·The Journal of Physical Chemistry. B·Maria Angélica C MassonThiago C Correra