Tacrolimus ameliorates cerebral vasodilatation and intracranial hypertension in the rat with portacaval anastomosis and hyperammonemia

Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Thomas DethloffFin Stolze Larsen

Abstract

Arterial hyperammonemia and cerebral vasodilatation correlate with cerebral herniation in patients with fulminant hepatic failure (FHF). Tacrolimus is a calcineurin inhibitor that passes the blood-brain barrier and may increase cerebrovascular tone and restrict cerebral ammonia influx. In this study, we determined if tacrolimus prevents cerebral vasodilatation and high intracranial pressure (ICP) in the rat with portacaval anastomosis (PCA) challenged to high arterial ammonia (NH4+) concentration. Seven groups of mechanically ventilated rats, with 6-9 rats in each group, were investigated within 48 hours after construction of a PCA (4 groups) or after sham operation (3 groups). Three groups of the rats received infusion of NH4+ and 4 groups received saline for approximately 180 minutes. Two groups of the PCA rats receiving either NH4+ or saline had an i.v. injection of tacrolimus (0.4 mg/kg) or vehicle before start of NH4+ or saline infusion. Cerebral blood flow (CBF) was monitored by a laser Doppler probe in brain cortex. ICP was monitored by placement of a catheter in the cerebrospinal fluid. CBF and ICP increased in PCA rats receiving NH4+ infusion compared to PCA controls and to all groups of sham-operated animals (P <.05)....Continue Reading

References

Mar 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·C IadecolaN A Lassen
Jan 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S AggarwalR Policare
Aug 1, 1996·Seminars in Liver Disease·F S Larsen
Mar 3, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J O ClemmesenP Ott
Nov 7, 1999·Journal of Hepatology·A T Blei, F S Larsen
Sep 26, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·N RolandoR Williams
Jul 14, 2001·Journal of Hepatology·R Jalan, R Williams
Aug 2, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C ChungA T Blei
Dec 1, 2001·Metabolic Brain Disease·K V Rao, M D Norenberg
Sep 5, 2002·Progress in Neurobiology·Vicente Felipo, Roger F Butterworth
Nov 9, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Fin Stolze Larsen, Julia Wendon
Jan 24, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Michael D Norenberg
Jan 28, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Shawn D St PeterDavid C Mulligan
Jun 26, 2003·Metabolic Brain Disease·K V Rama RaoD M Norenberg
Sep 2, 2003·Gastroenterology·Javier VaqueroAndres T Blei
Nov 7, 2003·Neurochemistry International·Peter Ott, Fin Stolze Larsen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

Blood Brain Barrier Regulation in Health & Disease

The blood brain barrier is essential in regulating the movement of molecules and substances in and out of the brain. Disruption to the blood brain barrier and changes in permeability allow pathogens and inflammatory molecules to cross the barrier and may play a part in the pathogenesis of neurodegenerative disorders. Here is the latest research in this field.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.