Tacrolimus combined with two different corticosteroid-free regimens compared with a standard triple regimen in renal transplantation: one year observational results

Clinical Transplantation
Bernhard K KrämerJohan Nordström

Abstract

Side effects of steroid use have led to efforts to minimize their use in transplantation. Two corticosteroid-free regimens were compared with a triple immunosuppressive therapy. Data from the original intent-to-treat (ITT) population (153 tacrolimus/basiliximab [Tac/Bas], 151 tacrolimus/MMF [Tac/MMF], and 147 tacrolimus/MMF/steroids [control]) were analyzed in a 12-month follow-up. Percentage of graft survival were 92.8%, 95.4%, and 95.9% (KM estimates 89.9%, 95.3%, 95.9%), percentage of surviving patients were 98.7%, 98.0%, and 100% (KM estimates 95.9%, 92.8%, and 100%). During months 7-12, graft loss occurred in 3 Tac/Bas, 2 Tac/MMF, and zero control patients, patient deaths in 1 Tac/Bas, 2 Tac/MMF, and zero control, and biopsy-proven acute rejection episodes in 4 Tac/Bas, 3 Tac/MMF, and zero control. Mean serum creatinine at month 12 was 141.9 +/- 69.6 microM, 144.0 +/- 82.1 microM, and 134.5 +/- 71.2 microM (ns). New-onset insulin use in previously non-diabetic patients at month 12 was 1/138, 6/127, and 4/126. Patient and graft survival as well as renal function at 12 months were not different between patient groups, despite considerably higher rates of acute rejection occurring within the first six months after transplanta...Continue Reading

References

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Citations

Sep 29, 2012·Clinical Pharmacokinetics·Troels K BergmannChristine E Staatz
Oct 18, 2012·Clinical Transplantation·Xin ZhangLiming Wang
Apr 18, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J D PirschE S Woodle
Sep 1, 2016·Health Technology Assessment : HTA·Tracey Jones-HughesRob Anderson
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Aug 23, 2016·The Cochrane Database of Systematic Reviews·Maria C HallerAngela C Webster
Mar 13, 2020·BMC Nephrology·Mysore K PhanishUNKNOWN South West Thames Renal Transplantation Network

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