Tacrolimus dosing requirements and concentrations in adult living donor liver transplant recipients

Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
David J TaberR Shrestha

Abstract

Living donor liver transplantation in adult recipients is becoming increasingly common. The liver metabolizes most drugs, including immunosuppressive agents. Right-lobe grafts used in adult living donor liver transplantation consist of only 50% to 60% of the total liver. The purpose of this study is to determine whether there is a difference between tacrolimus doses and concentrations in patients who received a partial liver transplant from a living donor (LRD) versus those who received a whole-liver transplant from a cadaveric donor (CAD). Thirteen LRD recipients and 13 CAD recipients who underwent transplantation between April 1998 and July 2000 were included in this analysis. A CAD control group matched for age, sex, and race was used for comparison. Tacrolimus doses and concentrations were analyzed weekly for the first 4 weeks, then monthly for 6 months posttransplantation. There was no difference in acute rejection rates, renal and liver function test results, or number of potentially interacting medications administered between groups. LRD recipients required significantly lower doses of tacrolimus compared with CAD recipients at 2 weeks (0.058 v 0.110 mg/kg/d; P <.01), 3 weeks (0.068 v 0.123 mg/kg/d; P <.02), 4 weeks (0....Continue Reading

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Citations

Nov 1, 2002·Current Treatment Options in Gastroenterology·James F. Trotter
Oct 4, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Gregory T Everson
Jul 13, 2004·Clinical Pharmacokinetics·Christine E Staatz, Susan E Tett
Aug 25, 2009·World Journal of Gastroenterology : WJG·Fei LiuJia-Yin Yang
Oct 21, 2005·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Koichi TanakaChristian Moench
Jan 30, 2009·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Patrick G NorthupUNKNOWN Adult-to-Adult Living Donor Liver Transplantation Cohort Study Group
Jul 20, 2011·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Giovanni VizziniBruno Gridelli
Mar 9, 2010·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Constantino FondevilaJuan C García-Valdecasas
Oct 7, 2005·Clinics in Liver Disease·Lawrence U Liu, Thomas D Schiano
Oct 4, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Mitchell L Shiffman
Sep 7, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Mark W Russo, Roshan Shrestha
Sep 18, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Mitchell L ShiffmanRobert A Fisher
Mar 24, 2006·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Sander Florman, Charles M Miller
Apr 26, 2019·The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG·Kensuke ShojiMureo Kasahara

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