Tacrolimus (FK506)--its effects on intestinal glucose transport

Transplantation
N L YancharD L Sigalet

Abstract

Tacrolimus (FK506) is at present the mainstay of immunosuppression for small intestinal transplantation. This study investigates the effects of chronic treatment with varying dosages of tacrolimus on animal well-being, weight gain, intestinal permeability, and the active transport of nutrients as measured by in vitro studies quantifying glucose flux. The effect of acute treatment with high-dose tacrolimus on glucose flux was also investigated. In the chronic studies, juvenile male Lewis rats were given tacrolimus in a dosage of 0.1 mg/kg, 0.5 mg/kg, and 2 mg/kg q. second day by subcutaneous injection for five weeks. In the acute studies, animals were treated with 2 mg/kg given q. 24 hr [mult] 48 hr, 24 hr and 12 hr prior to sacrifice. In the acute treatment groups, tacrolimus caused no change in glucose flux. In the chronically treated animals, FK506 levels were within the clinically relevant range. Chronic treatment with 0.5 and 2 mg/kg caused a significant reduction in weight gain. These same groups of animals had a significant increase in intestinal permeability as measured by absorption of 99Te-DTPA. Glucose flux was affected in all chronically treated groups, with net flux increasing in the jejunum and decreasing in the il...Continue Reading

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Citations

Nov 19, 2003·Indian Journal of Pediatrics·Olivier Goulet, Yann Révillon
Apr 2, 2008·The Journal of Experimental Medicine·Elizabeth E ForbesSimon P Hogan
Aug 27, 1997·Transplantation·G B WinkelaarD L Sigalet
Aug 24, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·O Goulet
Jan 11, 2001·Current Opinion in Clinical Nutrition and Metabolic Care·O GouletC Ricour
Jul 1, 1997·Journal of Pediatric Gastroenterology and Nutrition·O GouletC Ricour
Jan 7, 2011·Transplant International : Official Journal of the European Society for Organ Transplantation·Maciej MalinowskiMartin Stockmann
Feb 4, 1998·Baillière's Clinical Gastroenterology·O GouletC Ricour
Jul 27, 2000·Scandinavian Journal of Gastroenterology·M P Pakarinen, J Halttunen
May 1, 2001·Pediatric Transplantation·M FrühwirthH Ellemunter

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